中文摘要：

聚己内酯（PCL）是一种具有良好药物透过性的可生物降解的脂肪族聚酯，是一类优良的药物载体。由于其结晶性强，亲水性差，生物降解速度慢，限制了其在组织工程等生物医用领域更广泛的临床应用。在PCL主链上引入功能性官能团既可有效地降低其结晶性、改善其亲水性、调控其降解速率，同时又可通过反应性官能团进行进一步的化学改性或生物活性化修饰，已成为生物可降解材料新的研究热点。本文综述了含侧基官能团己内酯单体的合成及其聚合反应，简要介绍了侧基官能团对聚己内酯性能的影响。

英文摘要：

Poly（ε-caprolactone） （PCL） is a kind of aliphatic polyesters which is biodegradable, biocompatible and drug-permeable. However, the high crystallinity, low hydrophilicity and degradation rate limit its further applications in biomedical areas. Attachment of functional groups along the chain is highly desirable to tailor the macroscopic properties of these aliphatic polyesters, e.g. crystallinity, hydrophilicity, biodegradation rate, bioadhesion and mechanical properties. Moreover, pendent functional groups can be used to covalently attach molecules or probes of biological interest. In this article, the synthesis and ring-opening polymerization （ROP） of substituted ε-caprolactones were reviewed. Also the effect of functional groups to PCL was introduced briefly.