中文摘要：

趋化因子在阿尔茨海默病（Alzheimer＇s disease,AD）的发病机制中发挥多重作用。AD是一种中枢神经系统的慢性炎症性疾病,其神经病理学特征包括神经原纤维缠结（neurofibrillary tangles,NFT）、β淀粉样蛋白（amyloid beta protein,Aβ）斑块、神经炎症和神经元突触丢失。趋化因子通过激活或调节炎症细胞和神经胶质细胞参与AD的病理机制,发挥了促炎和抗炎双重作用。AD患者血清、脑脊液和脑组织中的趋化因子水平发生相应的变化。该综述总结了趋化因子及其受体在AD中的生物活性以及变化规律,为临床治疗AD提供新的策略。

英文摘要：

Chemokines play pleiotropic roles in the pathology of Alzheimer＇s disease（ AD）,a chronic inflammatory disease of central nervous system. The neuropathological features of AD include neurofibrillary tangles,amyloid plaques,neuroinflammation,and neuronal synaptic loss. Chemokines are involved in the pathogenesis of AD by activating or regulating inflammatory cells or glial cells,playing dual key roles of the pro-and anti-inflammatory properties in AD. The levels of chemokines in serum,cerebrospinal fluid and brain tissue of AD patients are changed accordingly. This review summarizes the role of chemokines and their receptors in AD in the biological activities and unveils the changing rules,aiming to provide new strategies for clinical treatment of AD.