中文摘要：

肠上皮细胞紧密连接（TJ）在肠道黏膜屏障中起着重要作用,其受损会导致细胞间的通透性增加,细菌、内毒素和大分子物质通过细胞旁路途径进入其他组织、器官或体循环,从而引发疾病。本文从蛋白角度和信号通路角度介绍肠上皮细胞TJ的研究进展,并进一步指出肠黏膜受到刺激后分泌大量的Zonulin蛋白,其与Zonulin受体结合,传导信号,调控TJ上Claudin、Occludin、JAM、ZOs、Cingulin等多种蛋白的表达,从而开放TJ。肿瘤坏死因子-α通过激活核转录因子κB p65/p50异源二聚体与启动子下游κB结合区域结合激活肌球蛋白轻链激酶转录启动子是TJ信号通路中较为成熟的通路。

英文摘要：

Intestinal epithelial tight junctions（TJ） plays an important role in the intestinal mucosal barrier, and the damage resultes in increased intercellular permeability, bacteria, endotoxin and macromolecules through the paracellular way into other tissues, organs or body circulation, causing disease. This article introduces the progress of studies on intestinal epithelial cell line TJ from the angle of view and protein signaling pathway, and further points out that the intestinal mucosa after stimulated to secrete large amounts of Zonulinprotein, combining with Zonulinreceptor, andzonulin receptor signal transduction, regulation of TJ on Claudin, Occludin, JAM, ZOs, the expression of Cingulin and other protein, so as to open TJ. Tumor necrosis factor-α through the activation of nuclear factor kappa B p65/p50 two dimer and heterologous promoter B binding domain binding activating myosin light chain kinase transcription promoter is the pathway of mature TJ signal pathway.