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老年基底节区脑出血早期神经功能恶化与预后的相关因素分析

ISSN号：1009-0126
期刊名称：《中华老年心脑血管病杂志》
时间：0
分类：R743.34[医药卫生—神经病学与精神病学;医药卫生—临床医学]
作者机构：[1]南京大学医学院临床医学院南京军区南京总医院神经内科,210002
相关基金：国家自然科学基金（31171016）;南京军区南京总医院医学科研课题（2012003）

作者：张晓浩[1], 马楠[1], 邱忠明[1], 张君[1], 谢霞[1], 刘德志[1], 刘新峰[1]

关键词：脑出血, 白细胞计数, 血糖, 血肿, 预后, cerebral hemorrhage , leukocyte count , blood glucose , hematoma , prognosis

中文摘要：

目的探讨老年基底节区脑出血早期神经功能恶化（END）与预后的关系.方法连续选择头颅CT确诊为基底节区脑出血的患者99例,根据是否发生END分为END组37例和非END组62例,90例患者完成90d随访,并根据预后情况分为预后良好组46例和预后不良组44例,分析相关影响因素.结果与非END组比较,END组入院加拿大卒中量表（CSS）评分[（5.6±1.9）分vs （7.1±1.9）分]、白细胞计数[（10.9±3.1）×10^9/Lvs （8.2±2.6）×10^9/L]、血肿体积[（17.6±20.2）ml vs （11.3±10.6）ml]及出血破入脑室比例（73.0％ vs 25.8％）等明显变化,差异有统计学意义（P＜0.05,P＜0.01）.与预后良好组比较,预后不良组入院CSS评分、白细胞计数、END、随机血糖、血肿体积及出血破入脑室比例有明显变化,差异有统计学意义（P＜0.01）.logistic回归分析显示,END是老年基底节区脑出血早期预后不良的独立危险因素（OR=5.602,95％CI：1.144-27.426,P=0.033）.结论老年基底节区脑出血发生END的患者早期预后较差.

英文摘要：

Objective To study the association of early neurological deterioration （END） and outcomes in elederly patients with cerebral hemorrhage in basal ganglia.Methods Ninety nine patients with cerebral hemorrhage in basal ganglia were divided into END group （n=37） and nonEND group （n=62）.Ninety out of the 99 patients,who were followed up for 90 days,were then divided into good outcome group （n=46） and poor outcome group （n=44）.Their outcomes-related factors were analyzed.Results The CSS score was significantly higher while the WBC count,hematoma volume and incidence of intraventricular hemorrhage were significantly lower in END group than in non-END group （5.6±1.9 vs 7.1±1.9,8.2±2.6 ×10^9/L vs 10.9±3.1×10^9/L,11.3±10.6 ml vs 17.6±20.2 ml,25.8% vs 73.0%,P〈0.05,P〈0.01）.The CSS score,WBC count,serum blood glusoe level,hematoma volume and incidence of intraventricular hemorrhage were significantly lower in poor outcome group than in good outcome group（P〈0.01）.Logistic regression analysis showed that END was an independent rtisk factor for the poor outcomes in patients with cerebral hemohrrage in basal ganglia （OR =5.602,95% CI：1.144-27.426,P =0.033）.Conclusion The early outcomes are poor in patients with END in basal ganglia hemorrhage.

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