中文摘要：

目前,环境重金属污染的情况日益加剧,使生物体的健康及其赖以生存的环境受到严重的威胁。为抵抗这种不良环境,生物体表现出的一种防御机制,即热休克蛋白基因的表达发生改变。在重金属暴露的条件下,热休克蛋白的表达在保护细胞免受损伤或使受损的细胞恢复功能等方面起到了重要作用。笔者综述了重金属对机体热休克蛋白70、90基因表达的影响及关系,并探讨了其可能的致病机制与现存的问题。

英文摘要：

At present, with the increasing of heavy metal pollution in the environment, the health of organisms and their survival environment are threatened seriously. To resist the unfavorable environmental conditions,organisms develop a defense mechanism that is the change of gene expression of heat shock protein. Under the condition of heavy metal exposure ,the expression change of heat shock protein plays an important role in protecting cells from damage or restoring damaged functions of cells. The effects of heavy metals on the expression of the heat shock protein 70 and 90 genes and their relationships were discussed in this paper, aiming to explore the pathogenic mechanism and the existing problems.