中文摘要：

调整动态 N 的酶上的最近的研究<啜class=“ a-plus-plus ”> 6 -methyl-adenosine ( m <啜class=“ a-plus-plus ”> 6 一)在和从 m 的调查结果的 RNA <啜class=“ a-plus-plus ”> 6 A甲醇化物 RNA immunoprecipitation 由高产量的定序列在后面( MeRIP-seq/m <啜class=“ a-plus-plus ”> 6 A-seq )揭示了 m 的一个宽广生物角色<啜class=“ a-plus-plus ”> 6 在 RNA 处理的 A ，开发，区别，新陈代谢和富饶。RNA m < 啜 class= “ a-plus-plus ” > 6 methylation 被由至少三个子单元组成的 multicomponent methyltransferase 建筑群催化：METTL3， METTL14 和 Wilms 肿瘤 1 伙伴蛋白质(WTAP ) ，在哪个 METTL3 和 METTL14 用作催化子单元，当时 WTAP 作为规章的子单元。Dioxygenases FTO 和 ALKBH5 开始的二已知的 m < 啜 class= “ a-plus-plus ” > 6 demethylases，催化 m < 啜 class= “ a-plus-plus ” > 6 移动。五 m < 啜 class= “ a-plus-plus ” > 6 A 绑定蛋白质被分类进细胞质的 YT521-B 相同(YTH ) 包含域的家庭 YTHDF13 和原子 YTHDC12。催化动态 m 的酶的活动的不安 < 啜 class= “ a-plus-plus ” > 6 A 导致几千基因的改变的表示并且影响 mRNA 稳定性并且在细胞的水平拼接。这里，我们关于 m 总结最近的发现<啜class=“ a-plus-plus ”> 6 methyltransferases (作家)， demethylases (橡皮)和有约束力的蛋白质(读者)，并且进一步讨论 m 的潜在的影响<啜class=“ a-plus-plus ”> 6 RNA 处理上的 A ，特别在拼接的 mRNA 上。

英文摘要：

Recent studies on enzymes regulating dynamic N6-methyl-adenosine （m6A） in RNA together with the findings from m6A-methylated RNA immunoprecipitation followed by high-throughput sequencing （MeRIP-seq/m6A- seq） have revealed a broad biological role of m6A in RNA processing, development, differentiation, metabolism and fertility. RNA m6A methylation is catalyzed by a multi- component methyltransferase complex composed of at least three subunits： METTL3, METTL14 and Wilms tumor 1-associated protein （WTAP）, in which METTL3 and METTL14 serve as catalytic subunits, while WTAP as reg- ulatory subunit. Dioxygenases FTO and ALKBH5, as the first two known m6A demethylases, catalyze m6A removal. Five m6A-binding proteins are classified into cytoplasmic YT521-B homology （YTH） domain-containing family YT- HDF1-3 and nuclear YTHDC1-2. Perturbation of enzy- matic activities catalyzing dynamic m6A results in altered expression of thousands of genes and affects mRNA stability and splicing at the cellular level. Here, we summarize recent discoveries about m6A methyltransferases （writers）,demethylases （erasers） and binding proteins （readers）, and further discuss the potential impacts of m6A on RNA pro- cessing, especially on mRNA splicing.