中文摘要：

系统性红斑狼疮（systemic lupus erythematosus,SLE）是一种免疫性性疾病。乳腺癌（breast cancer,BC）即乳腺恶性肿瘤,是女性常见的恶性肿瘤之一。乳腺癌患者体内众多免疫功能低下,其免疫系统无法识别并杀死癌细胞,然而,系统性红斑狼疮患者体内免疫系统反应过度强烈,产生大量抗体攻击自身细胞,可见两种疾病均与免疫系统息息相关但调控结果背道而驰,目前这一机制尚不明确。基于此,本研究从基因之间的关联性考虑,首先,利用互信息（mutual information,MI）方法筛选出1 250个SLE与BC共有显著基因;第二,将这些基因利用David分析,得到37个转录因子及其调控的378个靶基因,最后,采用快速网络成分分析算法（fast network component analysis,Fast NCA）分别预测SLE和BC发病过程中转录因子活性以及对靶基因调控强度的变化,并构建调控网络。经过两种疾病调控网络对比,发现AKT2、CCAR1、MTF2、RUFY2等基因在这两种疾病中活性变化明显相反,并且通过分子生物学分析,它们在有丝分裂,细胞凋亡,免疫反应以及炎症反应过程中的变化对SLE与BC的致病具有重要作用。

英文摘要：

Systemic Lupus Erythematosus（SLE） is anautoimmune bullous disease. Breast Cancer（BC） is a malignant tumor, which is one of the common malignant tumor for women. Breast cancer patients have low cell immune function, accordingly the immune system can＇t identify and kill cancer cells, however, the immune system of patients with systemic lupus erythematosus act very strongly, a large number of antibodies are generated to fight against their own cells, so the above two diseases are closely related to the immune system which work in opposite rules, unfortunately this mechanism is unclear now. Based on the above situation, this study considered the genetic correlation, firstly, we selected 1 250 genes which were distinct on both SLE and BC by using the method of Mutual Information（MI）; Secondly, we analyzed the genes with the David, then got 37 transcription factors and378 target genes controlled by these transcription factors, finally, we used the Fast NCA（fast network component analysis） to predict the activity of transcription factors and the intensity about the control to the target gene in SLE and BC separately during the attack of disease, and set up control network. After comparing the two control networks of the two diseases, we found that the activity of AKT2, CCAR1, MTF2, RUFY2 changed in contrast obviously in the two diseases, and through the analysis of molecular biology, we found that these changes of the genes in mitosis, apoptosis, immune response and inflammation had important impacts on the initiation of SLE and BC.