Platencin是西班牙土壤样品中平板链球菌(Streptomyces platensis)MA7339的代谢产物,骨架具有6/6/6三环笼状结构,能够抑制细菌脂肪酸的生物合成,具有良好的广谱抗菌活性.综述了自2010年以来platencin的全合成以及形式合成的研究进展,对各个路线的反应步骤进行了说明,对合成策略进行了重点讨论.
Platencin was isolated from a new strain of Streptomyces platensis MA7339 found in a soil sample collected in Spain. It has a novel molecular structure and exhibits a broad spectrum of antibacterial activity. In this review, the progresses since 2010 in the total synthesis of platencin are summarized with an emphasis on the synthetic strategies of the routes.