中文摘要：

[目的]观察荷丹片对非酒精性脂肪性肝炎（NASH）大鼠脂代谢的干预作用。[方法]雄性SD大鼠40只，随机分为4组：正常组、模型组、阳性对照组和治疗组。除正常组外，其余各组给予高脂饲料喂养，8周后开始药物灌胃干预，治疗4周后处死全部动物，应用全自动生化分析仪进行血清生化指标检测，油红0染色光镜下观察大鼠肝细胞脂肪变性情况。[结果]与模型组相比，荷丹片治疗后可明显减低NASH大鼠血清中丙氨酸氨基转移酶、天冬氨酸转氨酶和三酰甘油水平，升高高密度脂蛋白胆固醇水平。光镜观察荷丹片能明显缓解NASH大鼠肝细胞脂肪变性。[结论]荷丹片对高脂饮食诱导的大鼠NASH有一定的治疗作用。

英文摘要：

[Objective]To investigate the therapeutic effects of Hedan Tablet on lipid metabolism in rats with nonalcoholic steatohepatitis（NASH）. [Methods]Forty male SD rats were randomly divided into 4 groups：the normal group （n=10） ,the model group （n：10） ,the positive control group （n：10） and Hedan Tablet treated group （n： 10）. The normal group was fed with normal diet and the others with fat-rich diet for 8 weeks. After establishing NASH model, drugs were given to each group for 4 weeks. The serum levels of ALT, AST, TC, TG, HDL and LDL were measured with auto-biochemistry instrument. The patholog- ical morphology of liver tissues was observed by oil-red O staining. [Results]Compared with model group, the blood serum levels of ALT, AST, and TG reduced and HDL increased remarkably in Hedan Tablet treated group. Compared with model group, the morphological change in Hedan Tablet treated group was relieved. [Conclusion]Hedan Tablet is effective in the treatment of NASH rats induced by fat-rich diet.