执行控制障碍是成瘾的核心特征之一,对成瘾者的复发与康复治疗有重要影响。采用事件相关电位(ERP)技术分析海洛因戒治者和健康成年人在经典色-词Stroop任务中执行控制的大脑皮层时程动态变化。行为结果发现,两组被试的反应时均有显著的Stroop干扰效应,但无显著组间差异。ERP结果显示,戒治组不一致条件的平均波幅显著小于对照组;戒治组Stroop任务相关的N2效应和SP消失及N450效应衰减。研究结果表明,海洛因戒治者可能存在早期冲突监控加工障碍和晚期反应冲突解决加工异常。
Research Objectives Dysfunctional executive control is one of the core characters for the addiction, and it has important influence on the relapse and maintenance treatment for the heroin treatment patients(HTPs). The present study employs the event-related potentials (ERPs) technique to reveal the time course of information processing with high temporal resolution, and exam the altered function of conflict monitoring and conflict resolution processing among HTPs. Methods Seventeen HTPs (mean duration of heroin use(9.97±5.08)years with average abstinence (2.32±2.05)years) were chosen from Methadone Maintenance Treatment Clinic of No.2 People’s Hospital in Chongqing as HTPs group, and seventeen matched healthy adults were recruited from society as control group. All participants were conformed to the standards of the experiment, and performed a classic word-color Stroop task. The experimental materials contain two kinds of stimuli, the congruent stimuli were four color words whose meaning were congruent with the writing colors(eg, the word “red” written in red), and the incongruent stimuli were the same four color words whose meaning were incongruent with the writing colors(eg, the word “red” written in green). The experiment adopted mixed design of 2(condition types)×2(groups), and required the participants to response to the condition types by pressing the corresponding buttons. According to the experiment by the two response types of ERP average figures, the present study performed three factors of repeated measure of variance analysis (brain regions * condition types *groups) with nine electrode records sites, two within-subject factors were respectively brain regions [frontal areas(F3/Fz/F4), central areas(C3/Cz/C4) and parietal areas(P3/Pz/P4)], condition types (congruent/incongruent conditions), the between-subject factor was group types(HTPs /control). Results The results show that there are significant within-subjects Stroop inte