中文摘要：

这篇论文的目的是识别效果机械不用并且 trabecular 骨头的形式上的基本多细胞的单位(BMU ) 激活阀值在经绝期期间。一个骨头改编模型与机械 -- 在 BMU 的生物因素铺平与有限元素分析是综合的在经绝期期间模仿 trabecular 骨头结构的变化。机械不用，在 BMU 激活阀值的变化以前在经绝期以后从 4 年为时期被用于模型到 4 年。在骨头体积部分， trabecular 厚度和 trabecular 结构的分数维的尺寸的变化被用来确定在三个不同盒子中的 trabecular 骨头的变化与联系了机械不用并且 BMU 激活阀值。在模仿的骨头体积部分的变化高度被相关，这被发现并且与临床的数据一致，并且 trabecular 厚度在经绝期期间显著地减少了并且线性地高度与骨头体积部分被相关，并且模仿的 trabecular 结构的分数维的尺寸的变化趋势在与临床的观察的通讯。在这篇论文的数字模拟可以帮助更好理解在骨头形态学和机械，以及生物的环境之间的关系；并且能为结构的词法变化由机械环境，或生物环境引起了的骨头的数字模拟提供一个量的计算模型和方法论。

英文摘要：

The objective of this paper is to identify the effects of mechanical disuse and basic multi-cellular unit （BMU） activation threshold on the form of trabecular bone during menopause. A bone adaptation model with mechanical- biological factors at BMU level was integrated with finite element analysis to simulate the changes of trabecular bone structure during menopause. Mechanical disuse and changes in the BMU activation threshold were applied to the model for the period from 4 years before to 4 years after menopause. The changes in bone volume fraction, trabecular thickness and fractal dimension of the trabecular structures were used to quantify the changes of trabecular bone in three different cases associated with mechanical disuse and BMU activation threshold. It was found that the changes in the simulated bone volume fraction were highly correlated and consistent with clinical data, and that the trabecular thickness reduced signi-ficantly during menopause and was highly linearly correlated with the bone volume fraction, and that the change trend of fractal dimension of the simulated trabecular structure was in correspondence with clinical observations. The numerical simulation in this paper may help to better understand the relationship between the bone morphology and the mecha-nical, as well as biological environment; and can provide a quantitative computational model and methodology for the numerical simulation of the bone structural morphological changes caused by the mechanical environment, and/or the biological environment.