中文摘要：

基于环氧合酶-2（COX-2）与COX-1结构上的差异，设计了萘普生的噻唑衍生物，以期利用COX-2的侧面口袋，增加对COX-2的结合作用，以萘普生为原料经四步反应合成7个目标化合物，其结构经核磁共振氢谱、质谱和元素分析（或高分辨质谱）确证．体外筛选结果表明，化合物有一定的COX-2抑制活性．

英文摘要：

Based on the differences between cyclooxygenase-2 （COX-2） and COX-l, a series of derivatives of naproxen in which the carboxyl group was replaced with a variety of substituted thiazolyls were designed. Seven target compounds were synthesized in four steps with naproxen as a starting material and structurally confirmed by ^1H NMR, MS and elemental analysis or HRMS. The biological tests showed that some of them have inhibitory activity against COX-2 in vitro.