中文摘要：

目的：探讨绿茶多酚（GTPs）对帕金森病（PD）模型小鼠运动和学习记忆功能的影响,为GTPs用于治疗PD提供实验基础。方法：取40只雄性C57BL小鼠（25~30 g）,随机均分成正常组、模型组、GTPs低剂量组、GTPs高剂量组。模型组、GTPs低剂量组、GTPs高剂量组小鼠ip 1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）（30 mg/kg,qd）7 d造模后,分别进行Morris水迷宫、Rotor-rod实验、爬杆实验的检测。随后,GTPs低、高剂量组小鼠给予GTPs（ip,qd）14 d,模型组给予等容量生理盐水,并在给药完成的次日重复上述检测。结果：（1）与正常组相比,MPTP导致PD小鼠的Morris水迷宫测试的逃避潜伏期延长、爬杆实验的爬杆时间延长、Rotor-Rod实验的爬行持续时间缩短（n=10,均P〈0.05）;（2）与模型组相比,GTPs可以缩短PD小鼠的水迷宫逃避潜伏期、爬杆实验的爬杆时间,并延长Rotor-Rod实验的爬行持续时间（n=10或5,均P〈0.05）。结论：GTPs对PD模型小鼠运动和学习记忆功能具有一定的改善作用。

英文摘要：

AIM： To explore effects of green tea polyphenols（ GTPs） on motor,learning and memory functions of model mice of Parkinson＇s disease（ PD）and possibly to offer the experimental data of GTPs application on clinical PD patients. METHODS：Forty male C57 BL mice were randomly divided into normal group,model group,low dosage（ 100 mg /kg） and high dosage（ 625 mg / kg） group of GTPs.After administration of MPTP（ 30 mg / kg,ip,qd）for 7 days in mice of model group,low dosage group and high dosage group were prepared for PD animal model. Tests of Morris water maze,Rotor-rod system and pole-climbing were performed to evaluate the PD mice. Thereafter, mice in low and high dosage groups received GTPs treatment（ ip,qd） for 14 days,while model group mice were given equivalent amount of saline. The three types of tests were repeated on the 14 th day of GTPs treatment. RESULTS： MPTP application lengthened the escape latency of Morris water maze test and pole-climbing test,but shortened the lasting time of Rotor-rod system climbing（ P〈0. 05） as compared with the normal group（ n = 10）. Comparing to the model group,GTPs not only shortened the escape latency of Morris water maze and the time of pole-climbing,but also lengthened the lasting time of Rotor-rod system climbing（ n = 10 or 5,P〈0. 05）. CONCLUSION： GTPs may improve the motor,learning and memory functions in PD model mice.