中文摘要：

结直肠癌是目前严重威胁人类健康的常见消化系统恶性肿瘤,而转移为影响其预后的重要因素之一。结直肠癌转移的机制尚未完全清楚,有研究表明许多癌基因参与其转移过程,其中原癌基因Ras基因被激活后转变成癌基因参与肿瘤发生发展,目前在临床中已通过检测Ras基因状态进行靶向治疗。然而Ras基因的基因状态与转移性结直肠癌的总生存期具有一定相关性。本综述旨在针对K-Ras基因与转移性结直肠癌预后相关性的研究进展进行阐述。

英文摘要：

At present, colorectal cancer, a serious threat to human health, is a common digestive system malignant tumor.Metastatic colorectal cancer has an important prognosis factor, but the transfer mechanism is not fully clear. Studies have shown that many cancer genes are involved in the transfer process. The Ras gene belongs to the proto-oncogene,when it is activated, it can be transformed into cancer gene and participate in tumor occurrence and development. By detecting the Ras genes in the clinical and according to the state of gene, the targeted therapy can be taken. However,the overall survival of metastatic colorectal cancer has a certain correlation with the status of Ras gene. This review aims to state the research progress of the correlation between K-Ras gene and prognosis of metastatic colorectal cancer.