中文摘要：

目的：探讨细胞红蛋白（Cygb）在不同级别脑胶质瘤的表达及其在预后判断等方面的意义。方法采用免疫组织化学方法检测88例脑胶质瘤组织标本（WHOⅠ级10例，Ⅱ级37例，Ⅲ级26例，Ⅳ级15例）Cygb的表达情况，并分析其与临床病理、肿瘤复发和预后的关系。结果在低级别胶质瘤（Ⅰ～Ⅱ级）中Cygb呈高表达，在高级别胶质瘤（Ⅲ～Ⅳ级）中Cygb呈低表达。Kruskal-Wallis test分析Cygb的表达程度与胶质瘤的病理级别呈高度负相关（P＜0.01）；Mann-Whitney U test分析Cygb与胶质瘤术后是否复发也呈高度负相关（P＜0.01）。Cygb低表达组患者的生存率低于Cygb高表达组。Cox回归分析Cygb低表达为脑胶质瘤高风险因素之一。结论 Cygb的表达水平能作为判断脑胶质瘤恶性程度的另一个指标， Cygb的表达水平还可以作为判断脑胶质瘤患者的预后和是否复发指标之一。

英文摘要：

Objective To investigates the expression and significance of Cygb in human gliomas. Methods The expression of Cygb was detected by immunohistochemical methods in 88 cases of human glioma（10 cases of WHO grade Ⅰ, 37 cases of WHO grade Ⅱ, 26 cases of WHO grade Ⅲ, 15 cases of WHO grade Ⅳ）. Analyzed the relationships of the expression of Cygb with histological grades, tumor recurrence and the prognosis of the patients. Results High expression of Cygb was significantly associated with the lower histological grading（WHO grade Ⅰ-Ⅱ）, low expression of Cygb was significantly associated with the higher histological grading（WHO grade Ⅲ-Ⅳ）. The expression of Cygb had highly correlation with histological grades （P＆lt;0.01） and tumor recurrence（P＆lt;0.01）, respectively. Decreased Cygb expression affected survival in all cases （P＆lt;0.01）. Conclusion Cygb may be another indicator for the estimation of glioma malignant degree and predicting the prognosis and recurrence of glioma.