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中文摘要：
目的：比较麻醉态与清醒态兔单侧睾丸急性缺血对健侧睾丸血流动力学和病理的影响。方法：42只雄性健康大白兔,随机均分为麻醉组（A）和清醒组（B）,各组内再设对照组5只（A0/B0）、不全缺血组8只（A1/B1）、完全缺血组8只（A2/B2）。超声监测下制成单侧睾丸急性缺血模型。缺血组于精索结扎前、后及松解前后相应时间行睾丸超声造影;对照组于相应时间行睾丸超声造影并监测心率、血压。分析两种意识状态下健侧睾丸造影及组织结构变化情况。结果：戊巴比妥钠麻醉后,A组兔心率、血压明显受抑制。单侧睾丸急性缺血后,A组健侧睾丸各造影参数无显著变化;B组健侧睾丸短时间内造影参数峰值基础强度差（PBD）减少,显影时间（AT）、峰值减半时间（HT）延长。精索松解后,A1组、B1组、B2组短时间内PBD增高、HT延长。缺血组健侧睾丸均存在局灶性病理损伤和超微结构变化,但Johnsen＇s评分各组无显著差异;A1组、B1组、B2组健侧睾丸凋亡细胞显著增多。结论：急性睾丸血运障碍可对健侧睾丸造成一定程度的损伤。清醒状态下一侧睾丸急性缺血可引起健侧睾丸血流动力学短期内的变化,神经血管反射可能是一重要原因。麻醉剂对兔神经及心血管的抑制作用可使健侧睾丸血流灌注变化不显著。
英文摘要：
Objective： To compare the impact of unilateral acute testicular ischemia on the hemodynamics and histology of the contralateral testis of the rabbits under consistent anesthesia with that of the rabbits in the conscious state.Methods： Forty-two healthy male white rabbits were randomly divided into an anesthetic group（Group A） to receive injection of sodium pentobarbital（PS） and a non-anesthetic group（Group B）,each including a control group of 5 animals（A0 and B0）,an incomplete testicular ischemia group of 8（A1 and B1）,and a complete testicular ischemia group of 8（A2 and B2）.Testicular ischemia models were constructed by color Doppler ultrasonography.Contrast-enhanced ultrasound（CEUS） was used to observe the perfusion of the contralateral testes before and after ligating and loosening the unilateral spermatic cord in each experimental group.The control animals also underwent CEUS and measurement of the heart rate（HR） and blood pressure（BP） at the corresponding time.Histological structure changes in the contralateral testes of the rabbits were observed in both anesthetic and conscious states.Results： PS anesthesia markedly suppressed the HR and BP of the rabbits.The parameters in Groups of A0,A1 and A2 showed no statistically significant changes after unilateral ligation of the spermatic cord,while Groups B1 and B2 displayed significantly decreased peak-base difference（PBD） and prolonged arrival time（AT） and half time of descending peak intensity（HT）.Groups A1,B1 and B2 showed significantly increased PBD and prolonged HT shortly after loosening the spermatic cord.Focal pathological and ultrastructural changes were observed in the contralateral testes of the ischemic rabbits,but no significant difference was found in Johnsen＇s score in comparison with the controls.The apoptotic cells were remarkably increased in Groups A1,B1 and B2.Conclusion： Acute testicular ischemia may induce injury to the contralateral testis to some degree,and a reflexive sympathetic re
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