中文摘要：

分别以叠氮丙胺和丙炔胺为引发剂,采用氨基酸环内酸酐开环聚合法（NCA-ROP）,引发L-谷氨酸-γ-苄酯-N-羧基-环内酸酐和L-谷氨酸-γ-氯乙醇酯-N-羧基-环内酸酐聚合得到链端基为叠氮基的聚（L-谷氨酸-γ-苄酯）（PBLG）和链端基为炔基的聚（L-谷氨酸-γ-氯乙醇酯）（PCELG）均聚物.联合点击化学法（click chemistry）制备了一系列聚（L-谷氨酸-γ-苄酯）-b-聚（L-谷氨酸-γ-氯乙醇酯）（PBLG-b-PCELG）,再通过对嵌段共聚物侧基氯进行化学修饰,将二代的甲基烷氧醚类亲水性树形枝化分子（G2）接枝到侧链上,形成一系列树形支化分子接枝聚肽双亲性嵌段共聚物,通过核磁（NMR）、红外光谱（IR）和凝胶渗透色谱（GPC）对其化学结构进行了表征,并采用紫外-可见光谱（UV-Vis）研究了聚合物结构及其溶液浓度对其温敏行为的影响规律.

英文摘要：

A series of novel amphiphilic block copolypepides bearing the hydrophilic second-generation（G2） dendritic ether grafts denoted as PBLG-b-（PELG-g-G2） were designed and synthesized by a combination of ring-opening polymerization and click chemistry. First, azido-terminated poly（γ-benzyl-L-glutamate）s（PBLG） with different molecular weights were synthesized by ring-opening polymerization of γ-benzyl-L-glutamate-Ncarboxyanhydride（BLG-NCA） in DMF at room temperature using 3-azido-1-propanamine as initiator and alkyne-terminated poly（γ-2-chloroethyl-L-glutamate）（PCELG） was synthesized by ring-opening polymerization of γ-2-chloroethyl-L-glutamate-N-carboxyanhydride in DMF at room temperature using propargylamine as initiator. The block copolypeptides poly（γ-benzyl-L-glutamate）-block-poly（γ-2-chloroethyl-L-glutamate）（PBLGb-PCELG） bearing chloride side groups were synthesized by click chemistry with high efficiency from the azido-terminated PBLG and the alkyne-terminated PCELG in the presence of Cu Br and 1,1,4,7,7-pentamethyldiethylenetriamine（PMDETA） catalyst system. Then, PBLG-b-PCELG containing chloride side groups was subsequently reacted with excessive sodium azide in DMF to yield a block copolypeptide bearing azido side groups denoted as PBLG-b-（PNELG）. The hydrophilic second-generation（G2） dendritic ethers were finally grafted to the side chains of the block copolypeptides PBLG-b-（PNELG） by click chemistry in the presence of Cu Br/PMDETA catalyst system and the amphiphilic dendronized block copolypepides PBLG-b-（PELG-g-G2） were successfully synthesized. Their molecular structures were further characterized by1H-NMR, FTIR and GPC. The thermo-responsive behaviour of PBLG-b-（PELG-g-G2） in water were investigated using UV-Vis and the results showed that the values of the cloud point temperatures（Tcp） of PBLG-b-（PELG-gG2） became lower with the length increase of the hydrophobic PBLG chain segment. This was explained by the fact that the amphip