中文摘要：

目的：明确5-HT1A受体是否参与吻侧无颗粒岛叶皮层（rostral agranular insular cortex,RAIC）介导的抗炎性持续性痛效应。方法：采用行为药理学实验方法观察RAIC内微量注射选择性5-HT1A受体激动剂和拮抗剂对福尔马林诱发的伤害性行为（缩足反应）的影响。结果：RAIC内微量注射选择性5-HT1A受体的激动剂8-OH-DPAT（5.0μg/0.5μl）明显抑制福尔马林诱发的大鼠缩足反应;向RAIC内提前5min预先微量注射5-HT1A受体拮抗剂NAN-190（10μg/0.5μl）则可拮抗8-OH-DPAT（5.0μg/0.5μl）对缩足反应的抑制效应;RAIC内单独注射NAN-190对福尔马林诱发的大鼠缩足反应没有影响。结论：5-HT1A受体参与RAIC介导的抗炎性持续性痛效应。

英文摘要：

Objective：To investigate whether 5-hydroxytryptamine 1A（5-HT1A）receptor in the rostral agranular insular cortex（RAIC）are involved in mediating the descending anti-persistent inflammatory nociceptive effects.Methods：The effects of microinjection of the selective 5-HT1A receptor agonist and antagonist on the formalin-evoked nociceptive behavior（flinching response）using animal behavior pharmacological method.Results：Microinjection of the selective 5-HT1A receptor agonist 8-OH-DPAT（5.0 μg/0.5 μl）into the RAIC depressed the formalin-evoked flinching responses,which was antagonized by pre-treatment with the selective 5-HT1A receptor antagonist NAN-190（10 μg/0.5 μl）in the same RAIC site.Microinjection of NAN-190 alone into the RAIC has no influence on the formalin-evoked flinching responses.Conclusion：These results suggest that 5-HT1A receptor in the RAIC are involved in mediating the descending antinociceptive effects on the persistent inflammatory nociception.