中文摘要：

以往临床研究发现高血压病患者发生2型糖尿病的风险增加，阻断肾素．血管紧张素系统（RAS）对于预防2型糖尿病的发生具有一定的保护作用。近期研究还表明，RAS可能直接参与了糖尿病发生发展过程。炎性反应是肥胖、2型糖尿病等代谢性疾病的重要分子基础。血管紧张素介导的氧化应激、炎性反应水平以及游离脂肪酸的增加在局部和全身都对机体产生重要的影响。

英文摘要：

Patients with essential hypertension are at the increased risk of type 2 diabetes. Several recent clinical trials have suggested that blockade of the rennin-angiotensin system （RAS） may protect against the development of de-novo diabetes in ＇at risk＇ patients. Evidences show that the RAS may play a direct role in the pathogenesis of diabetes. Angiotensin-mediated increases in oxidative stress, inflammation, and free fatty acids concentrations potentially are involved the process to diabetes.