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中文摘要：
目的 研究成年大鼠细胞周期蛋白依赖激酶（CDK）在神经元和星型胶质细胞的表达.方法 应用免疫荧光和激光扫描共聚焦显微镜观察成年大鼠生理状态下大脑皮层或海马CA1区神经元和星型胶质细胞CDK1、CDK2、CDK4的表达.结果 成年大鼠大脑皮层和海马CA1区神经元的细胞核和细胞浆均有CDK1、CDK2和CDK4表达,以胞核为主;星形胶质细胞也有CDK1、CDK2和CDK4的表达,但表达细胞数目较少,且表达这些指标的星形胶质细胞多聚集在海马CA1区.结论 成年大鼠大脑皮层和海马区的神经元和星形胶质细胞均表达CDK,而神经元的CDK表达较星形胶质细胞更为普遍.
英文摘要：
[ Objective ] To study the difference of CDK between astrocytes and neurons in adult rats. [ Method] The expressions of CDK1 ,CDK2,CDK4 of astrocytes and neurons on cerebral cortex or hippocampal CA1 region of adult rats were detected by immunofluorescence and confocal microscope. [ Result] All CDKs were expressed on nuclear or/and cytoplasm of postmitotic neurons, mainly on nuclear, of cerebral cortex or CA1 subfield of hippocampus; Whereas only a few astrocytes expressed CDKs in adult hippocampus and cerebral cortex and most of these astrocytes were located on hippocampal CA1 region. [ Conclusion ] Both astrocytes and neurons were expressed all CDKs in adult rats hippocampus and cerebral cortex. Compared with that of the astrocytes, the expressions of CDKs on mature neurons were remarkable.
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