中文摘要：

身体尺寸是在生物世界上把一种与另外一个区分开来的特征之一。动物开发了机制在正常开发期间控制他们的身体尺寸。然而，动物怎么应付基因改变或环境压力糟糕发展成正常大小的成年人遗体，理解。动物的能力揭示身体尺寸控制的坚韧性在基因改变或环境压力的挑战以后发育成一个正常大小的成年人。这里，我们证明 dGPAT4 的变化， lysophosphatidic 酸的 de novo synthase，是在果蝇触发动物的如此的柔韧的回答到身体尺寸挑战的基因改变。dGPAT4 的损失在幼虫的阶段期间导致开发，慢生长和结果的小型的动物的严重延期，但是导致正常大小的成年苍蝇。dGPAT4 异种的柔韧的身体尺寸调整被相应变化多半在蜕皮激素完成，胰岛素发信号，它是也由损害食物吸入表明了。因此，我们建议策略被动物发展了当由基因改变质问了时，到达最后的身体尺寸，它要求协调蜕皮激素并且胰岛素发信号。

英文摘要：

Body size is one of the features that distinguish one species from another in the biological world. Animals have developed mechanisms to control their body size during normal development. However, how animals cope with genetic alterations and/or environmental stresses to develop into normal-sized adults remain poorly understood. The ability of the animals to develop into a normal-sized adult after the challenges of genetic alterations and/or environmental stresses reveals a robustness of body size control. Here we show that the mutation of dGPAT4, a de novo synthase of lysophosphatidic acid, is a genetic alteration that triggers such a robust response of the animals to body size challenges in Drosophila. Loss of dGPAT4 leads to a severe delay of development, slow growth and resultant small-sized animals during the larval stages, but results in normal-sized adult flies. The robust body size adjustment of the dGPAT4 mutant is likely achieved by corresponding changes in ecdysone and insulin signaling, which is also manifested by compromised food intake. Thus, we propose that a strategy has been evolved by the animals to reach final body size when challenged by genetic alterations, which requires the coordinated ecdysone and insulin signaling.