中文摘要：

目的探讨大鼠肥厚心肌结构重构、交感神经重构机制及他汀药物的保护作用。方法62只雄性Wistar大鼠行腹主动脉缩窄术，8周造成压力超负荷性心肌肥厚模型，分为肥厚组和瑞舒伐他汀组，另设22只作为假手术组。瑞舒伐他汀组灌胃给药（10mg·kg^-1·d^-1）连续12周后进行超声心动图和血流动力学指标测定。免疫组化法测定心肌中酪氨酸羟化酶（TH）和生长相关因子43（GAP43），Western印迹法检测心肌的TH、GAP43和神经生长因子（NGF）表达水平。结果（1）肥厚组左室重量（LVW）、左室重量指数（LVWI）、室间隔厚度（IVSd）、左心室后壁厚度（PWd）、左心室舒张末期内径（LVEDd）、左心室收缩末压（LVSP）、收缩期左心室内压最大变化速率（＋dp／dtmax）和舒张期左心室内压最大变化速率（-dr／dtmax）均高于假手术组和瑞舒伐他汀组。（2）Western印迹显示，肥厚组比假手术组，NGF、GAP43分别增加了1．5倍和1．7倍。瑞舒伐他汀组均低于肥厚组，分别降低46．4％（0．82±0．06比1．53±0．10）和16％（0．68±0．06比0．81±0．10）。肥厚组比假手术组，TH水平降低45．7％（0．44±0．10比0．81±0．10），瑞舒伐他汀组（0．62±0．06）比肥厚组增高41％。结论压力超负荷性大鼠肥厚心肌出现结构重构、交感神经重构现象；他汀药物能改善肥厚心肌的结构重构和交感神经重构。

英文摘要：

Objective To explore the remodeling mechanism of myocardium and sympathetic nerve in pressure overload left ventricular hypertrophy and elucidate the protective effect of statins. Methods Pressure-overload left ventrieular hypertrophy （LVH） of rats was induced by partial coarctation of abdominal aorta; a sham-operated group served as the control （SHAM, n = 22）. At 8 weeks post-operation, the animals were divided into two groups and a 12-week treatment period was investigated. At the end of treatment period, echocardiographic evaluations and hemodynamic measurements were performed. Sympathetic innervation was investigated by analyzing nerve growth factor （NGF） , growth associated protein- 43 （GAP43） and tyrosine hydroxylase （TH）. Results In LVH rats, a significant increase of left ventrieular weight, left ventricular weight/body weight, echoeardiographie left ventricular end-diastolic diameter, interventrieular septum thickness, posterior left ventricular wall thickness, left ventrieular systolic pressure and dP/dt was observed. The expressions of NGF and GAP43 protein were significantly down-regulated （0.82 ±0.06 vs 1.53 ±0. 10, 0.68 ±0.06 vs 0.81 ±0. 10） and TH level was up-regulated （0. 44 ± 0. 10 vs 0. 62 ± 0. 06） by RSV treatment. Conclusion A HMG CoA inhibitor reverses the development of left ventrieular hypertrophy and inhibits sympathetic innervation in abdominal aortic-clamped animals.