中文摘要：

目的：探讨帕金森病大鼠氧化应激反应及绿茶多酚的干预作用。方法：采用6-羟基多巴胺（6-OHDA）偏侧损毁纹状体制备帕金森病大鼠模型，并随机分为模型组、绿茶多酚组，另取正常对照组、假手术组大鼠，每组10只。分别在6周后进行神经行为学检测后，取纹状体，应用比色法分别测定各组大鼠纹状体内超氧化物歧化酶（SOD）、丙二醛（MDA）、谷胱甘肽（GSH）、谷胱甘肽过氧化物酶（GSH-Px）的含量。结果：帕金森病模型组大鼠纹状体内SOD、GSH、GSH—Px的含量均明显减少，MDA含量呈增加趋势；而绿茶多酚组大鼠纹状体内SOD、GSH、GSH—Px的含量均呈现增加趋势，MDA含量呈减少趋势。结论：绿茶多酚能较好地改善帕金森病大鼠的氧化应激反应，可能通过清除自由基，减轻对细胞的损伤，从而缓解帕金森病的症状。

英文摘要：

Objective： To discuss oxidative stress reactions of the rats with Parkinson＇s disease and the intervention of green tea polyphenols. Methods： Rat model with Parkinson＇s disease was prepared by 6-OHDA damaging corpus striatum unilaterally, and they were randomized into the model group and green tea polyphenols group, normal control group and sham operation group were established, ten rats each group. After detecting neuroethology in six weeks respectively, the contents of SOD, MDA, GSH, GSH-Px in corpus striatum of the rats were measured respectivelyby using colorimetry. Results： The contents of SOD, GSH and GSH-Px in the model group of Parkinson＇s disease lowered obviously, the contents of MDA showed a rise tendency, while the contents of SOD, GSH and GSH-Px in the green tea polyphenols group showed a rise tendency, while the contents of MDA demonstrated a decrease tendency. Conclusion： Green tea polyphenols could improve oxidative stress reactions of the rats with Parkinson＇s disease, and it could relieve the symptoms of Parkinson＇s disease by eliminating free radicals and relieving cellular damage.