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中文摘要：
前列腺素E2（PGE2）是一种不饱和脂肪酸,具有多种生理活性,由环氧合酶（COX）在炎症刺激下合成.PGE2能抑制髓系祖细胞分化,促进红系祖细胞增生,对造血系统有着重要的调节作用,近期研究发现用PGE2增加造血干细胞（HSC）数量,体外可以减少HSC的凋亡,提高HSC的长期移植重建能力和归巢能力,提示PGE2对HSC有重要的调控作用.此外,PGE2还可以增强辐射损伤后HSC造血系统的重建能力,维持造血系统的稳定性.PGE2调节HSC机制的研究表明,PGE2可以通过抑制活性氧自由基的产生来防止HSC的过度分化,另外还可以通过Wnt信号通路起到维持HSC稳态的作用.将经PGE2处理后的脐带血移植到灵长类动物体内已被证实是安全的,预示着PGE2在骨髓移植中有着潜在的重要临床意义.该文将对最近几年PGE2对HSC的调控作用的相关研究进行综述.
英文摘要：
Prostaglandin E2 （PGE2）is a bioactive lipid molecule produced by cyclooxygenase （COX）,which plays an important role on hematopoiesis.While it can block differentiation of myeloid progenitors but enhance proliferation of erythroid progenitors.Recent research found that PGE2 have the effects on hematopoietic stem cell（HSC） function and these effects were independent from effects on progenitor cells.Exposure of HSC cells to PGE2 in vitro can increase homing efficiency of HSC to the murine bone marrow compartment and decrease HSC apoptosis,meanwhile increase long-term stem cell engraftment.In-vivo treatment with PGE2 expands short-term HSC and engraftment in murine bone marrow but not long-term HSC.In addition,PGE2 increases HSC survival after radiation injury and enhance hematopoietic recovery,resulting maintains hematopoietic homeostasis.PGE2 regulates HSC homeostasis by reactive oxygen species and Wnt pathway.Clinical beneficial of 16,16-dimethyl-prostaglandin E2 treatment to enhance engraftment of umbilical cord blood suggest important improvements to therapeutic strategies.
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