中文摘要：

近年来研究发现调节性树突状细胞（Dendritic cells,DC）能够下调免疫应答和介导外周免疫耐受,调节性DC诱导的免疫耐受与其未成熟或半成熟状态密切相关。大量研究表明调节性DC和调节性T细胞（Regulatory T cells,Treg）之间存在着复杂的双向调控：调节性DC可扩增和诱导产生Treg,还可影响Treg向局部组织和外周淋巴器官归巢;Treg则妨碍DC与非调节性T细胞的结合并抑制DC的活化、成熟和刺激T细胞增殖的能力。总之,调节性DC与Treg相互协同以精细调控机体的免疫应答。

英文摘要：

Regulatory dendritic cells （DC） are responsible to peripheral tolerance for its remarkable down-regulation of immune reactions. The immature and semi-mature state contributes to the suppressive property of DC. Accumulated evidence has shown that interaction between regulatory DC and regulatory T cells （Treg） plays a crucial role in the balance between immune response and tolerance. Regulatory DC has been demonstrated involvement in the expansion, generation of Treg as well as modification of Treg’s chemotaxis to local tissues and secondary lymphoid organs. Conversely, Treg renders DC tolerogenic by competing with T cells for attachment to DC, inhibiting DC maturation, and blocking the priming of T cells by DC. On the whole, regulatory DC and Treg work in concert to keep a fine regulation of immune responses.