中文摘要：

在缺氧条件下，线粒体会产生大量的活性氧（reactive oxygen species， ROS），随即大量的活性氧将会诱导机体产生缺氧应激反应。缺氧诱导因子1（hypoxia inducible factor 1， HIF？1）是缺氧应激反应中的中枢调控因子。有研究表明， ROS主要通过抑制脯氨酸羟化酶家族（prolyl hydroxylases， PHDs）的活性来抑制HIF？1α的泛素化降解，从而稳定HIF？1。而HIF？1蛋白水平的升高有助于机体应对缺氧微环境。最近研究还发现， REDD？1可以通过ROS对HIF？1产生负调控作用，从而抑制肿瘤的形成；秀丽线虫呼吸突变体的产生会导致ROS水平增加，从而增强HIF？1的活性，最终延长的线虫寿命；以及ROS、 HIF？1促进自噬的产生。因此，了解缺氧条件下ROS与HIF？1之间的相互作用关系，对于今后肿瘤、衰老和自噬的研究具有重要意义。

英文摘要：

Under hypoxic condition, mitochondria can produce large amounts of reactive oxy-gen species （ ROS） , which will induce hypoxic stress response-Hypoxia-inducible factor 1 （ HIF-1 ） is a central regulator in hypoxic stress response-Many studies showed that ROS stabilized HIF-1 by inhibiting the activity of the prolyl hydroxylases （ PHDs） and thereby the ubiquitin degradation of HIF-1α-Upregulated levels of HIF-1 protein benefit organisms against hypoxia-Recently, it was also found that REDD-1 could cause negative feedback control of HIF-1 by regulating ROS and therefore suppress tumorigenesis-In the respiration mutant C-elegans model, the activity of HIF-1 was enhanced by increased ROS, leading to the longevity of C-elegans-ROS and HIF-1 can promote cell autophagy-Therefore, understanding the interaction between HIF-1 and ROS is of important sig-nificance for future researches on tumor, aging and autophagy.