中文摘要：

目的观察短效、长效奥曲肽及溴隐亭序贯应用治疗侵袭海绵窦的生长激素型垂体瘤的疗效。方法将16例侵袭海绵窦的生长激素型垂体瘤患者随机分为观察组和对照组,各8例。观察组患者先皮下注射短效奥曲肽,每次100μg,3次/d,持续1周;然后臀部肌肉深部注射长效奥曲肽,20 mg/次,每28 d注射1次,连用3次;然后口服嗅隐亭7.5 mg/d,3个月。对照组患者臀部肌肉深部注射长效奥曲肽,每次20 mg,每28 d注射1次,连用6个月。观测并比较两组患者治疗前、后的临床症状评分、血清GH谷值、血清胰岛素样生长因子1（IGF-1）、肿瘤体积。统计两组患者胃肠道不良反应发生情况及总治疗费用。结果两组患者治疗前后的临床症状评分、血清GH谷值、血清IGF-1、肿瘤体积组间比较P均〉0.05。观察组2例（25%）、对照组5例（62.5%）发生胃肠道不良反应,两组胃肠道不良反应发生率相比P〈0.05。观察组总费用为（33 000±2 000）元,对照组为（55 000±9 000）元,观察组低于对照组（P〈0.05）。结论短效、长效奥曲肽及溴隐亭序贯应用治疗侵袭海绵窦的生长激素型垂体瘤疗效与单用长效奥曲肽相当,但是能够避免胃肠道不良反应,减轻患者的药物经济负担。

英文摘要：

Objective To observe the efficacy of short-term, long-term octreotide and bromocriptine in the sequential treatment Of growth hormone pituitary adenoma invading the cavernous sinus. Methods Sixteen patients with growth hor- mone pituitary adenoma invading the cavernous sinus were randomly divided into two groups, 8 in each. Patients in the ob- servation group were given subcutaneous injection of short-term octreotide 100μg each time, 3 times/d for 1 week. Then, the long-term octreotide was deep injected into the buttock muscle, 20 mg each time, once every 28 days, for 3 times, fol- lowed by oral sniffing 7.5mg/d, for 3 months. The patients in the control group were deep injected with long-term octreotide, 20 mg each time, once every 28 days, for 6 months. The clinical symptom scores, serum GH valleys, serum IGF-1 and tumor volume before and after treatment were observed and compared between these two groups. Statistics on gastroin- testinal a~dverse reactions and total treatment costs between the two groups was conducted. Results No significant difference was found in the clinical symptoms score, serum GH valleys, serum IGF-1, tumor volume between the two groups before and after treatment （ all P 〉 0.05 ）. The incidence of gastrointestinal adverse reactions in the observation （ 2 cases ） was lower than that （5 cases） in the control group （25% vs 62.5% ）, P 〈 0.05. The total cost of the observation group was （33 000 ±2 000） yuan, which was lower than that of the control group [ （55 000±9 000） yuan], P 〈0.05. Conclusions The efficacy of short-term, ira,g-term octreotide and bromocriptine in the sequential treatment of growth hormone pituitary adenoma invading the cavernous sinus is the same as the only use of long-term octreotide, but short-term, long-term octreotide and bromocriptine can decrease the gastrointestinal adverse reaction and total cost of the treatment.