中文摘要：

目的研究熵指数在静吸复合全麻恢复期中的应用，并与双频谱指数（BIS）比较。方法ASAⅠ～Ⅱ级择期腹部手术患者15例，入室后常规监测生命体征，然后静注异丙酚、维库溴铵、芬太尼进行快诱导气管插管，持续吸入异氟烷，间断推注维库溴铵和芬太尼维持麻醉。采用自身对照试验设计，对每例患者同时监测熵指数（包括反应熵和状态熵）和BIS，以呼唤有反应作为意识恢复时点，分别于入室后，意识恢复前60、45、30s，意识恢复即刻，意识恢复后30、45、60s记录数据。结果反应熵、状态熵和BIS预测意识恢复的概率分别为0．9376、0．9252和0．9019，三者比较无显著性差异（P〉0．05），预测概率与反应熵、状态熵和BIS的Logistic回归方程分别为1n[Pk／（1-Pk）]=-19．825＋0．243x、In[Pk／（1-Pk）]=-18．012＋0．236x和1n[Pk／（1-Pk）]=-21．780＋0．316z；三者判断意识恢复的界值分别为83、76和71，其灵敏度／特异度分别为0．90／0．85、0．89／0．80和0．88／0．78；反应熵预测意识恢复比双频谱指数早30s。结论熵指数是较BIS更准确、更灵敏的新型脑电监护指标，可用于临床预测麻醉恢复。

英文摘要：

Objective To explore the application of Spectral Entropy as a new electroencephalographic measure during recovering period of general anesthesia, and to compare it with bispectral index （BIS）. Methods Fifteen ASA Ⅰ-Ⅱ patients undergoing elective abdominal surgery were studied. Anesthesia was induced with propofol, vecuronium and fentanyl. After intubation anesthesia was maintained with isoflurane inhalation combined with intermittent injections of vecuronium and fentanyl. With a self-control design, each case was monitored with Spectral Entropy, including response entropy （RE） and state entropy （SE）, and BIS simultaneously. It was defined that the response to verbal commands as the time point of regaining consciousness, then read the data at following time points： baseline values, 60s, 45s, and 30s before regaining consciousness, the moment of regaining consciousness, 30s, 45s, and 60s after regaining Results Prediction probabilities of RE, SE and BIS for regaining consciousness were 0. 9376, 0. 9252 and 0. 9019, respectively, and no statistically significant difference was found between them （P〉0. 05）. Furthermore, logistic regressive equations of prediction probability and RE, SE, BIS were calculated as In [Pk/（1-Pk）]=-19. 825＋0. 243X, In [Pk/（1-Pk）]=--18. 012＋0. 236x and In [Pk/（1-Pk）]=-21. 780＋ 0. 316x, respectively. From the perspective of sensitivity/specificity, RE, SE and BIS had threshold values for regaining 83, 76 and 71 with sensitivity/specificity of 0. 90/0. 85, 0. 89/0. 80 and 0. 88/0. 78, respectively. RE was 30s earlier than BIS in predicting regaining consciousness. Conclusion Compared with BIS, entropy index seems to be a more accurate and sensitive electroencephalngraphic measure, and is promising in clinical application.