中文摘要：

目的研究高血压病患者血浆维生素D（VitD）、D-二聚体（DD）含量与高血压患者脑静脉血栓形成的关联性，为高血压患者提供健康咨询意见。方法将高血压患者分为运动组和普通组。用全自动免疫荧光分析法测定各组血浆DD含量，运用ELISA法测定患者血清VitD含量，分别统计各组数据；发放问卷调查患者生活习惯，将每周坚持户外运动不少于10公里者定义为运动组（A组50例），其余定义为普通组（B组50例）；对所有患者进行头颅彩色多普勒超声检查，判断头部静脉血栓形成情况，分析该结果与VitD、DD含量的相关性；定期监测各组血压控制情况；追踪研究对象持续时间为1年，以评价VitD、DD含量与高血压患者血压控制、脑静脉血栓形成的关联性。另选50例健康体检者作为对照组（C组）。结果A组、B组、C组DD含量分别为（597±163）μg／L、（615±201）μg／L、（85±15）μg／L；A组、B组与对照组比较，差异有统计学意义（P〈0．05）。A组、B组、C组收缩压分别为（144±16）mmHg、（145±27）mmHg、（115±6）mmHg，舒张压分别为（87±9）mmHg、（89±10）mmHg、（71±5）mmHg，收缩压变异系数（CV1）分别为11．4％、18．9％、6．7％，舒张压变异系数（CV2）分别为10．7％、12．0％、9．4％；A组、B组收缩压变异系数差异有统计学意义（P〈0．01），舒张压变异系数差异无统计学意义（P〉0．05）。A组、B组、C组25羟基维生素D{25（OH）D}水平分别为（87．8士29．7）nmol／L、（34．9±18．9）nmol／L、（101．0±25．5）nmol／L，组间两两比较差异有统计学意义（P〈0．05）；A组中2例脑静脉血栓患者及B组中6例脑静脉血栓患者血浆DD含量分别为（1067±189）μg／L、（1160±177）μg／L，差异无统计学意义（P〉0．05）。结论非运动组高血压患者普遍存在VitD含量不足或缺乏；运动组收缩压变化?

英文摘要：

Objective To research the correlation between the levels of vitamin D （VitD） and D-dimer （DD） and cerebral venous thrombosis in patients with hypertension and to provide some references for health advice. Methods Hypertensive patients were divided into an exercise group and a normal group. Each group＇s plasma DD level were determined with automatic immune fluorimetry, and serum VitD level ELISA. The results were counted respectively. The patients＇ life habit was investigated through questionnaires; the patients doing more than 10 km outdoor exercise weekly were set as an exercise group（group A, n=50）, others a normal group（group B, n=50）. All patients were cranially examined with Doppler ultrasound to judge the formation of head vein thrombosis and the results were compared. All groups＇ blood pressure were regularly detected for one year to assess the correlation between the levels of VitD and DD and blood pressure in patients with cerebral venous thrombosis. 50 healthy people were chosen as a control group（group C）. Results The level of DD was （597±163） μg/L in group A, （615±201） μg/L in group B, and （85±15） μg/L in group C, with statistical differences between groups A and B and group C （P〈0.05）. The systolic pressure and diastolic pressure were （144±16） mmHg and （87±9） mmHg in group A, （145±27） mmHg and （89±10） mmHg in group B, and （115±6） mmHg and （71±5） mmHg in group C. The coefficient of variation （CV1） of systolic pressure was 11.4% in group A, 18.9% in group B, and 6.7% in group C, with a statistical difference between group A and group B （P〈0.01）; the coefficient of variation （CV2） of diastolic pressure was 10.7% in group A, 12.0% in group B, and 9.4% in group C, with no statistical difference between group A and group B （P〉0.05）. The levels of 25-hydroxyvitamin was （87.8±29.7） nmol/L in group A, （34.9±18.9） nmol/L in group B, and （101.0±25.5） nmol/L in group C, with statistical differences