中文摘要：

雷替曲塞是特异性胸苷酸合成酶抑制剂，作为新型细胞毒药物，其应用于多种实体肿瘤的治疗，具有效果好、不良反应轻、使用方便等优点。尤其在结直肠癌治疗领域，其疗效得到认可。临床应用中，雷替曲塞不仅可联合化疗药物或靶向药物使用，而且可作为放疗增敏剂。我们就近年来国内外雷替曲塞治疗结直肠癌的进展进行综述。

英文摘要：

Raltitrexed is a kind of specific thymidylate synthase inhibitor,and as a novel cytotoxic drug, it is used in the treatment of a variety of solid tumors,with the advantages of good effect,light adverse reaction and easy to use?Especially in the treatment of the colorectal cancer,its efficacy has been recognized?And in clin?ical,raltitrexed can plug with chemotherapy or targeted drug combination,as well as radiosensitizer?This review summarized the raltitrexed research progress on the treatment of colorectal cancer in recent years.