中文摘要：

作为功能的分叉的一个索引，在副本基因拷贝之间的表示分叉被观察了并且与在基因编码顺序分叉和偏爱的蛋白质相关功能的班。然而，在被认为到的副本基因的 cis 规章的区域的变化在表示分叉有重要角色，没在染色体宽的规模上被探索。我们为古老的 polyploidy 事件在 Arabidopsis thaliana 形成的很多复制基因对分析了功能的 genomics 数据。在在二个拷贝之间的 cis 规章的区域的分叉断然与表示的大小差别被相关。而且，我们发现高度表示的副本基因对比微弱地表示的基因对有一个更多的分叉的 cis 规章的区域。我们也证明在表示之间的关联功能的限制是的功能的限制和蛋白质在旧、年轻的副本对不同。我们的结果建议那 cis 规章的顺序分叉贡献染色体宽的复制形成的副本基因的表示分叉。Cis 规章的区域在高度表示的副本对更快分叉。对 cis 规章的区域和蛋白质编码区域起作用的 diversify 选择力量否定地在表示限制下面在年轻副本对被相关。

英文摘要：

As an index of functional divergence, expression divergence between duplicate gene copies has been observed and correlated with protein coding sequence divergence and bias in gene functional classes. However, the changes in the cis-regulatory region of the duplicate genes which is thought to have important role in expression divergence, has not been explored on the genome-wide scale. We analyzed functional genomics data for a large number of duplicated gene pairs formed by ancient polyploidy events in Arabidopsis thaliana. The divergence in cis-regulatory regions between two copies is positively correlated with the magnitude difference of expression. Moreover, we find that highly expressed duplicate gene pairs have a more diverged cis-regulatory region than weakly expressed gene pairs. We also show that the correlation between expression functional constraint and protein functional constraint is different in old and young duplicate pairs. Our results suggest that cis-regulatory sequence divergence contributes to the expression divergence of duplicate genes formed by genome-wide duplication. Cis-regulatory region diverges faster in highly expressed duplicate pairs. The diversify selection strengths that act on cis-regulatory region and protein coding region are negatively correlated in young duplicate pairs under expression constraint.