中文摘要：

目的探索儿茶酚胺氧位甲基转移酶（Catechol-O-methyltransferase,COMT）基因val158met多态性与社区健康老人综合认知训练效果的关系。方法对90名≥70岁的社区健康老人进行12周共24次的综合认知训练,干预前后采用中国老年成套神经心理测验（neuropsychological test battery for elderly,NTBE）评定认知功能,并通过TaqMan探针单核苷酸多态性基因分型技术检测COMT基因val158met多态性。结果基线时,COMT基因val158met多态性met等位基因携带组（n=38）组和未携带组（n=52）之间NTBE各项分测验成绩的差异均无统计学意义（P〉0.05）。干预后,未携带met等位基因组NTBE 4项分测验成绩优于携带组（P〈0.05）;而与基线比较,未携带met等位基因组NTBE的成绩13项提高（P〈0.05）,1项下降（P〈0.05）;携带met等位基因组8项提高（P〈0.05）,3项下降（P〈0.05）。结论 COMT基因val158met多态性与社区健康老人综合认知训练效果可能相关。

英文摘要：

Objective To explore the relationship between the genetic polymorphism of Catechol-O-methyltrans-ferase（COMT） val158met and efficacy of comprehensive cognitive training in healthy community elderly.Methods COMT val158met was genotyped through TaqMan single nucleotide polymorphism genotyping assay in 90 community healthy elderly aged 70 years or over who received cognitive interventions in small group settings in 24 sessions over 12 weeks.All individuals were assessed using Neuropsychological Test Battery for Elderly（NTBE） and a questionnaire ＂Shanghai Health Survey for the Elderly（Vervison 2006）＂ in baseline and follow-up phase.Results There were no significant differences in NTBE between elderly subjects with and without met allele before cognitive intervention.After intervention,4 subscales of NTBE in elderly subjects without met allele were better than those with met allele.In addition,13 subscales of NTBE improved and 1 subscale declined in elderly people without met allele（P0.05） whereas 8 subscales improved and 3 subscales declined in elderly people with met allele（P0.05）.Conclusions Effects of comprehensive cognitive training in healthy community elderly may be associated with the polymorphism of COMT val158met.