中文摘要：

白血病抑制因子（LIF）是一种肌肉因子（myokines）,在损伤骨骼肌和运动后骨骼肌中高丰度表达,它可能通过JAK2和STAT3信号通路调节肌卫星细胞和成肌细胞增殖,通过PI3K信号通路抑制成肌细胞凋亡,也可以通过LIF受体信号通路调节骨骼肌局部炎症反应,同时与多种细胞因子相互作用抑制成肌细胞过早分化,从而在骨骼肌损伤修复和骨骼肌肥大中发挥重要作用。外源性补充重组LIF可促进骨骼肌损伤修复和促进骨骼肌肥大,这具有非常重要的临床应用价值。LIF可能成为治疗急性肌肉损伤和促进骨骼肌肥大的一种新手段,有关LIF在骨骼肌方面的研究也将会成为一个新的研究热点。

英文摘要：

Leukaemia inhibitory factor（LIF） is a kind of myokines and high experssion after exercise and injury. It may get through JAK2 and STAT3 signaling pathways regulating muscle satellite cells and myoblast proliferation, get through PI3 K signaling pathway to inhibit myoblast apoptosis, regulate the skeletal muscle local inflammatory, interaction with various factors suppress the advanced differentiation of myoblast, helping skeletal muscle regeneration and skeletal muscle hypertrophy. The supplement of exogenous recombinant LIF can promote the repair of skeletal muscle injury and promote skeletal muscle hypertrophy, which has very important value in clinical application. LIF may become a new treatment method of acute muscle injury and promote skeletal muscle hypertrophy. And the research about LIF in skeletal muscle will also become a new hotspot.