中文摘要：

目的总结对大环内酯类抗生素耐药的肺炎支原体（MP）菌株感染所致MP肺炎（MPP）患儿的临床特点。方法选取2004年9月-2005年12月首都医科大学附属北京友谊医院儿科疑似MPP的住院患儿200例,应用巢式PCR和DNA测序技术检测64例确诊MPP患儿咽拭子标本MP耐药基因,在此基础上区分出耐药组和敏感组;观察2组患儿在性别、年龄、病程、最高体温、发热时间、住院时间、肺外并发症方面的差异,并应用SPSS11.5软件对其结果进行分析。结果 64例患儿中,咳嗽64例（占100%）,发热64例（占100%）;肺部有中细湿啰音52例（占81.3%）,粗湿啰音2例（占3.1%）,无肺部体征10例（占15.6%）;有肺外并发症11例（占17.2%）;胸部X线表现右肺病变者26例（占40.6%）,左肺23例（占35.9%）,双肺11例（占17.2%）,无具体病灶4例（占6.3%）。外周血白细胞正常53例（占82.8%）。耐药组和敏感组患儿在性别（P=1.000）、年龄（P=0.800）、最高体温（P=0.082）、肺外并发症发生率（P=0.113）方面比较,差异无明显统计学意义;耐药组患儿的发热天数（P=0.024）、病程（P=0.047）和住院时间（P=0.015）均高于敏感组。结论耐药MP株感染者与非耐药MP株感染者相比,发热时间长,病程长,住院时间长。

英文摘要：

Objective To summarize the clinical feature of children infected with macrolide-resistant mycoplasma pneumoniae（MP） isolate.Methods Sixty-four clinical isolates of MP from 200 children hospitalized in Beijing Friendship Hospital Affiliated to Capital Medical University from Sep. 2004 to Dev. 2005 were determined by a nest-PCR and DNA sequencing.The patients were divided into 2 groups （drug-resistant group and drug susceptive group） depending on whether had MP drug resistant gene. Age,sex,course,maximum temperature,length of stay,febrile days and complications were compared between the 2 groups.The SPSS 11.5 software was used to analyze the data.Results Of these 64 cases of MPP, 64 cases （100% ）of the patients had cough and fever,52 cases（81.3%） of the patients had fine wet rales,2 cases（3.1%） had coarse wet rales,and 10 cases（15.6%） of the patients did not have pulmonary signs, 11 cases （17.2%） had complications;chest X-ray revealed right lung lesions in 26 patients（40.6%）,left lung lesions in 23 patients （35.9%）, both lung lesions in 11 patients（17.2%）,and nothing in 4 cases;routine blood test revealed that white blood cells were normal in 53 patients（82.8%）.Compared to drug-susceptive group, febrile days（P=0.024）,course（P=0.047）and length of stay （P=0.015）were longer in drug-resistant group, but no significant differences were found in sex（P=1.000）, age（P=0.800）, the highest body temperature（P=0.082） and complications（P=0.113）.Conclusions Compared to infected by MP without drug resistant gene,those infected by MP with drug resistant gene, febrile days,length of stay and course were longer.