中文摘要：

吖啶类衍生物是一类含氮的有机杂环化合物,由于其在抗炎、抗菌及抗肿瘤方面体现了较好的生物活性而受到了广泛关注。本文对近年来吖啶类化合物在抗肿瘤方面的国内外研究成果进行了综述,对其主要作用靶点如端粒酶、拓扑异构酶Ⅰ/Ⅱ、微管蛋白、ABCG2/P-glycoprotein（P-gP）以及蛋白激酶等方面的研究进行了介绍,并指出该类化合物的发展方向及应用前景。

英文摘要：

Acridines are a series of heterocyclic compounds, which have been received intense interest and used as anti-inflammatory, antibacterial and antitumour agents. This paper reviews some recent progresses in the research of the antitumor activity of acridine derivatives, including as the inhibition of telomerase, topoisomerases Ⅰ and Ⅱ , tubulin, ABCG2/P-gP, protein kinases, etc. The prospects and potential applications of such acridine compounds are outlooked.