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Reduction of Glucose Metabolism in Olfactory Bulb is an Earlier Alzheimer＇s Disease-related Biomarker in 5XFAD Mice

ISSN号：0366-6999
期刊名称：《中华医学杂志：英文版》
分类：Q255[生物学—细胞生物学] Q78[生物学—分子生物学]
作者机构：[1]Department of Neurology and Geriatrics, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China, [2]Key Laboratory of Brain Aging and Neurodegenerative Diseases, Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, Fujian 350001, China
相关基金：This work was supported by grants from the National Natural Science Foundation of China （No. 91232709, No. 811171216, and No. 81161120496 for Prof. Xiao-Chun Chen, and No. 81200991 for Prof. Xiao-Dong Pan） and the National and Fujian Province＇s Key Clinical Specialty Discipline Construction Programs.

作者： Nai-An Xiao[1], Jing Zhang[1,2], Meng Zhou[1,2], Zhen Wei[1,2], Xi-Lin Wu[1,2], Xiao-Man Dai[1,2], Yuan-Gui Zhu[1,2], Xiao-Chun Chen[1,2]

关键词：抗凋亡蛋白, 内质网应激, 神经元, 阿尔茨海默病, 小鼠, 早期, 诱导, 家族性, Alzheimer＇s Disease, Amyloid β, Apoptosis： Endoplasmic Reticulum Stress, Unfolded Protein Response Pathway

中文摘要：

Address for correspondence： Prof. Xiao-Chun Chen, Department of Neurology and Geriatrics, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China Key Laboratory of Brain Aging and Neurodegenerative Diseases, Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou 350001, China E-Mail： chenxc998@163.com

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