中文摘要：

微小 RNA（miRNA）与肿瘤的发生发展密切相关。miR-139是一种具有抑癌作用的miRNA分子，在多种肿瘤组织中表达降低，而过表达 miR-139可通过多种靶基因抑制肿瘤细胞的增殖、迁移和侵袭，并诱导其凋亡。因此，miR-139在肿瘤的临床诊断、治疗及预后判断等方面具有潜在的应用前景。

英文摘要：

MicroRNA （miRNA）is closely related to the occurrence and development of neoplasms. miR-139 is a tumor-suppressive miRNA and its expression is decreased in a variety of tumor tissues,while over-expression of miR-139 can inhibit cancer cell proliferation,migration,invasion and induce cell apoptosis by suppressing the expression of multiple kinds of target genes.Therefore,miR-139 has potential applications in tumor diagnosis,treatment and prognosis assessment.