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Fatty acid desaturase 1 polymorphisms are associated with coronary heart disease in a Chinese population

ISSN号：0366-6999
期刊名称：《中华医学杂志：英文版》
分类：Q949.206[生物学—植物学] Q346.5[生物学—遗传学]
作者机构：[1]Department of Epidemiology and Biostatistics, Key Laboratory ofModem Toxicology of Ministry of Education, School of PublicHealth, Nanjing Medical University, Nanjing, Jiangsu 210029,China, [2]Department of Cardiology, Zhong Da Hospital, SoutheastUniversity, Nanjing, Jiangsu 210009, China, [3]Key Laboratory of Nutrition and Metabolism, Institute forNutritional Sciences, Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences, Graduate School of the ChineseAcademy of Sciences, Shanghai 200031, China
相关基金：This study was supported by grants from the National Natural Science Foundation of China （No. 81102180 and No. 30800947）, the Science ＆ Technology Supporting Projects （Social Development） of Jiangsu Province, China （No. BE2009681）, and the National Basic Research Program of Jiangsu Province, China （No. BK 2011776）.

作者： LIU Si-jun[1], ZHI Hong[2], CHEN Pei-zhan,[3], CHEN Wei[1], LU Feng[1], MA Gen-shan[2], DAI Jun-cheng[1], SHEN Chong[1], LIU Nai-feng[2], HU Zhi-bin[1], WANG Hui[3], SHEN Hong-bing[1]

关键词：脂肪酸去饱和酶, 基因多态性, 中国人口, 冠心病, 高密度脂蛋白胆固醇, HDL-C, 全基因组, 甲羟戊酸, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, triglyceride, polymorphisms, coronary heart disease, fatty acid desaturase I

中文摘要：

背景 A 在白种人的最近的染色体宽的协会学习揭示了那三 loci (在丰满的酸 desaturase 的 rs174547 1 ( FADS1 )， mevalonate kinase/methylmalonic aciduria 附近的 rs2338104 ，维生素B12 缺乏， cblB 类型( MVK/MMAB )和 rs10468017 接近肝的脂肪分解酵素( LIPC ))影响高密度的脂蛋白胆固醇(高级数据链路控制)和 triglycerides ( TG ) .However 的血浆集中，在中国 individu 在这些多型性和血浆类脂化合物集中之间的协会上有很少报告

英文摘要：

Background A recent genome-wide association study in Caucasians revealed that three loci （rs174547 in fatty acid desaturase 1 （FADS1）, rs2338104 near mevalonate kinase/methylmalonic aciduria, cobalamin deficiency, cblB type （MVK/MMAB） and rs10468017 near hepatic lipase （LIPC）） influence the plasma concentrations of high-density lipoprotein-cholesterol （HDL-C） and triglycerides （TG）. However, there are few reports on the associations between these polymorphisms and plasma lipid concentrations in Chinese individuals. This study aimed to evaluate the associations between these three polymorphisms with HDL-C and TG concentrations, as well as coronary heart disease （CHD） susceptibility in Chinese individuals.

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