中文摘要：

目的探讨阿司匹林是否能辅佐降低低氧性肺动脉高压患者的肺动脉胝计分析其可能的机制。方法符合研究标准的60例低氧性肺动脉高胝患者为研究对象，采用随机单盲的方法分为对照组（n=30）、治疗组（n=30）。对照组采用基础治疗包括病因治疗、氧疗、利尿剂、血管扩张剂，治疗组在基础治疗的基础上口服拜阿司匹林．每天100mg、持续30d．分别于治疗第0天及第30天测定两组患者下列参数：肺动脉收缩压（sPAP）、血清5-羟色胺（5-HT）及血柃素A2（TXA2）、血浆D-二聚体（D—dimer）、6rain步行距离（6MWD）。分析两组患者治疗前后上述参数的变化。结果与对照组比较，治疗组在治疗前参数sPAP、5-HT、TXA2、D—dimer、6MWD变化无统计学意义（P〉0．05）；治疗后sPAP、5-HT、TXA2、D—dimer较对照组降低、6MWD升高（P〈0．05）。治疗组治疗后sPAP、5-HT、TXA2、D-dimer明显下降（P〈0．05），而6MWD明显上升（P〈0．05）。两组患者所测定的sPAP与5-HT、TXA2、D-dimer呈正相关，相关系数分别为r1=0．732、F2=0．863、r=0．693。结论阿司匹林可辅佐降低低氧性肺动脉高压患者的肺动脉压；可能的机制与阿司匹林抑制血小板功能、降低血清5-羟色胺、血栓素A2水平及改善血液高凝状态、抑制肺内血栓形成有关。

英文摘要：

Objective To investigate whether the effect of aspirin can assist to reduce the puhnonary arterial pressure for the patients with hypoxie pulmonary hypertension （HPH）, also analyze the possible mechanism further. Methods A total of 60 eases diagnosed with hypoxie puhnonary hypertension which fitted on the study criterions were for study sut）jects, which were divided into control groups （nl=30） and treatment groups （n2=30） by random anti single-blind method. The basic treatment was applied on the control groups, included etiological therapy, oxygen therapy, diuretics and vasodilalors; besides of the basic treatment, the treatment groups received oraling aspirin 100 mg once a day for 30 （lays. The following parameters in two groups were measured respectively at the day before and after treatment： sys- tolic pulmonary arterial pressure （sPAP）, the level of serum 5-hydroxytryptamine （5-HT） and thromboxane A2（TXA2）, the level of plasma 1）-dimer, 6 minute ward distance （6MWD）. Then the variation of above parameters were analysed. Results Compared with the control groups： the variation of the parameters in treatment groups before treatment, such as sPAP ,5-HT ,TXA2 ,D-dimer,6MWD had no statistical significanee（P 〉 0.05 ）. and after treatment, sPAP,5-HT, TXA2 and D-dimer had decreased, 6MWD had increased, which had statistical significance （P 〈 0. 05 ）. Compared with ilself, tire variation of parameters before and after treatment in control groups had no statistical significance; but the variation in the treatment groups had obvious change which had statistical significance： such as sPAP,5-HT,TXA2 and D-dimer was reduced（P 〈 0. 05）, but 6MWD was risen（P 〈 0. 05）. The relationship between sPAP and 5- HT, TXA2, D-dimer were positive ton＇elation, its coefficient of correlation was r1=0.732, r2=0.863, r3=0.693 respectively. Conclusion Aspirin （：an assist to reduce the pulmonary arterial pressure for the patients with HPH. The possible mechanism would be as