中文摘要：

目的探讨大姚县受青石棉污染的生活饮用水与消化道恶性肿瘤死亡风险的关系。方法选取已有27年队列人群（n：1249）中因消化道恶性肿瘤死亡的研究对象作为病例组（n=54），并按年龄、性别、死亡时间等匹配因素，选取108名对照，进行1：2匹配的病例．对照研究，分析当地饮水情况对消化道恶性肿瘤死亡风险的影响。结果Logistic回归分析表明，使用石棉炉的时间越长，消化道癌症死亡危险性越高（使用6～10年：OR=2．920，95％CI1．501～5．604；使用11～15年：OR=3．966．95％CI2．156～7．950；使用15年以上：OR=4．122，95％CI1．211～7．584），喝生水导致消化道癌症死亡危险性增高（OR=1．43，95％CI1．07～1．88），饮水类型与消化道恶性肿瘤死亡危险性相关，与饮用自来水比较，饮用井水的风险为OR=1．770，95％CI1．001～2．444，饮用河水的风险为OR=2．442，95％C10．956～3．950，饮用宅泯沟水的风险为：OR=2．554，95％CI1．961～6．584，饮用池塘水的风险为OR=3．121，95％C，1．872～6．566。结论青石棉污染区饮水相关因素与大姚县主要消化道恶性肿瘤死亡有较强的关联。

英文摘要：

Objective To explore the relationship of eroeidolite pollution in drinking water with the risk of gastrointestinal cancer＇ s death in Dayao County. Methods A 1 ： 2 matched ease-control study involving 54 death cases of gastrointestinal cancer from a population-based cohort of twenty-seven years and 108 controls matched by age, gender, death time, ete was conducted to analyze the effect of local water condition on the risk of gastrointestinal cancer in Dayao County. Results Results from logistic regression analysis suggested the longer of asbestos furnace use over time, the higher the mortality risk of gastrointestinal cancer （6 - 10 years： OR = 2. 920, 95% CI 1. 501 -5. 604. 11 - 15 years： OR =3.966, 95% CI 2. 156 -7.950. Over 15 years： OR =4. 122, 95% CI 1.211 -7. 584）. Drinking unboiled water leaded to an increased risk of gastrointestinal cancer （OR = 1.43,95% CI 1.07 - 1.88 ）. Type of drinking water was associated with gastrointestinal cancer. When compared with drinking tap water, OR for drinking well water was 1.770 （95% CI 1.001 -2.444）, 2. 442 for drinking river water （95% CI 0. 956- 3. 950）, 2. 554 for drinking house and field ditch water （95% C1 1. 961 - 6. 584）, and 3. 121 for drinking pond water （95% CI 1. 872 -6. 566）. Conclusion Related factors of drinking water in crocidolite-contaminated area in Dayao County were significantly associated with the mortality of gastrointestinal cancer.