中文摘要：

目的：探讨骨折手术感染患者应用血清降钙素原（PCT）检测指导抗菌药物使用的临床意义，为抗菌药物应用提供参考依据。方法选取2012年2月－2014年2月204例骨折手术后感染患者，随机分为普通组与治疗组，各102例，普通组常规应用抗菌药物治疗，治疗组在治疗过程中检测PCT，根据PCT改变实施抗菌药物方案，对比两组抗菌药物使用时间、剂量及炎性反应指标。结果治疗组患者抗菌药物使用时间（4．39±1．59）d、费用（1032．54±128．43）元及住院时间（7．49±2．11）d 均少于普通组，对比差异有统计学意义（t＝5．394、8．493、7．194；P＜0．05）；治疗组治疗后 IL-6为（31．64±9．65）ng／L、CRP为（5．34±2．46）μg／L、白细胞指数为（13．65±6．32）×10^9／L，均低于普通组，对比差异有统计学意义（t＝8．232、6．403、7．432；P＜0．05）。结论根据 PCT检测结果实时改变抗菌药物使用方法，可有效减少抗菌药物滥用，提升治疗效果。

英文摘要：

OBJECTIVE To explore the clinical significance of detection of serum procalcitonin （PCT）in the fracture patients with postoperative infections so as to provide guidance for use of antibiotics.METHODS A total of 204 fracture patients with postoperative infections who were treated from Feb 2012 to Feb 2014 were enrolled in the study and randomly divided into the common group and the treatment group;the common group was given the conventional drug therapy,while the treatment group was treated with antibiotics based on the change of the PCT level;the time of use of antibiotics,dosage,and inflammatory reactions indicators were observed and compared between the two groups.RESULTS The time of use of antibiotics of the treatment group was （4.39±1.59）days, the cost of antibiotics （1032.54±128.43）yuan,the length of hospital stay （7.49±2.11）days,less than those of the common group,there was significant difference （t=5.394,8.493,7.194;P〈0.05）.After the treatment, the IL-6 level of the treatment group was （31.64±9.65）ng/L,the CRP level （5.34±2.46）μg/L,the white blood cells counts （13.65±6.32）×10^9/L,lower than those of the common group,there was significant differ-ence （t=8.232,6.403,7.432;P〈0.05）.CONCLUSION It is an effective way to use the antibiotics based on the results of monitoring of PCT so as to reduce the abuse of antibiotics and raise the curative effect.