中文摘要：

目的探讨过氧化物还原酶1（Prx1）与上皮细胞间质转化（EMT）相关蛋白在胰腺癌组织中的表达及其临床意义。方法采用免疫组化法分别检测Prx1、E-钙黏素（Ecadherin）、波形蛋白（Vimentin）在66例胰腺癌组织和11例正常胰腺组织中的表达,并分析三者之间的关系及与临床病理因素间的关系。结果 Prx1、E-cadherin和Vimentin分别在66例胰腺癌组织中的阳性表达率为69.70%（46/66）、40.91%（27/66）、56.06%（37/66）;Prx1、E-cadherin和Vimentin分别在11例正常胰腺组织中的阳性表达率为18.18%（2/11）、90.90%（10/11）、18.18%（2/11）。Prx1、E-cadherin和Vimentin在胰腺癌组织中的表达均与TNM分期、淋巴结转移和肿瘤分化程度显著相关（P〈0.05）,而与性别、年龄、肿瘤大小、病变部位均无关;Prx1与神经侵犯显著相关（P〈0.05）,而E-cadherin和Vimentin与神经侵犯无关。Prx1的表达与Vimentin表达呈正相关（P〈0.05）,Prx1和Vimentin的表达均与E-cadherin表达呈负相关（P〈0.05）。结论Prx1与EMT相关蛋白在胰腺癌组织中的表达呈显著相关性,并与其侵袭转移能力相关,提示Prx1的高表达可能为预测胰腺癌患者预后不良的辅助指标之一。

英文摘要：

Objective To investigate the expression clinical significance of Peroxiredoxin 1 （Prxl） and epithelial mesenchymal transition （EMT） -related factors in pancreatic carcinoma. Methods The expression of Prxl, E-cad- herind and Vimentin were detected in 66 pancreatic carcinoma samples and 11 normal pancreatic tissues by immu- nohistochemical method. The correlation between Prxl, E-cadherin, Vimentin and clinicopathologic characteristics was also analyzed. Results The positive expression rates of Prxl, E-cadherind and Vimentin were 69.70% （46/ 66）, 40. 91% （27/66） and 56.06% （37/66） in pancreatic carcinoma, and 18.18% （2/11）, 90.90% （ 10/ 11 ） and 18. 18% （2/11） in normal pancreatic tissue, respectively. The expression rates of Prxl, E-cadherin and Vimentin were correlated with TNM stage, lymph node metastasis, degree of differentiation （ P 〈 0. 05 ）. Prxl expression was correlated with nerve invasion in pancreatic carcinoma tissue （P 〈 0. 05 ）. The expression rates of Prxl, E-cadherin and Vimentin were not correlated with sex, age, size, site of tumor. E-cadherin and ~imentin expression were not correlated with nerve invasion inpancreatic carcinoma tissue. Prxl expression in pancreatic car- cinoma was positively correlated with Vimentin expression （P 〈 0. 05 ） ; Prxl and Vimentin were negatively correla- ted with E-cadherin expression （P 〈 0. 05）. Conclusion Prxl, E-cadherin and Vimentin expressions are associ- ated with the ability of invasion and metastasis in pancreatic carcinoma, Prxl abnormal expression maybe serve as a potential poor prognostic marker of patients with pancreatic carcinoma.