甲酰肽受体(FPR ) 被观察在啮齿类动物膨胀并且最近作为候选人 vomeronasal 被建议化学感应的受体。自从 vomeronasal,化学感应的受体通常经历了积极选择并且与 vomeronasal 机关(VNO ) 和谐地演变形态学,我们极大地在 VNO 形态学是的在首领调查了 FPR 多样并且因此,它将提供我们 VNO-FPRs 的一个更清楚的看法进化。由屏蔽可得到的首领染色体序列,我们在代表性的首领种类获得了 FPR 全部剧目。作为结果,我们没在首领发现 FPR 家庭尺寸扩大。进一步的分析没显示出在首领之间的进化力量变化与或没有 VNO 结构,它显示在首领 FPR 之中没有功能的分叉。我们的结果建议首领缺乏 VNO 特定的 FPR 和 FPR 扩大不是在在啮齿类动物系外面的哺乳动物的普通现象,不管 VNO 复杂性。
Formyl peptide receptors (FPRs) were observed to expand in rodents and were recently suggested as candidate vomeronasal chemo-sensory receptors. Since vomeronasal chemosensory receptors usually underwent positive selection and evolved concordantly with the vomeronasal organ (VNO) morphology, we surveyed FPRs in primates in which VNO morphology is greatly diverse and thus it would provide us a clearer view of VNO-FPRs evolution. By screening available primate genome sequences, we obtained the FPR repertoires in representative primate species. As a result, we did not find FPR family size expansion in primates. Further analyses showed no evolution-ary force variance between primates with or without VNO structure, which indicated that there was no functional divergence among pri-mates FPRs. Our results suggest that primates lack the VNO-specific FPRs and the FPR expansion is not a common phenomenon in mammals outside rodent lineage, regardless of VNO complexity.