中文摘要：

目的评估多奈哌齐治疗放射性脑病导致的认知功能障碍的疗效及安全性。方法回顾性研究既往55例确诊为放射性脑病出现认知功能障碍的患者，按是否服用多奈哌齐治疗分为治疗组（多奈哌齐＋神经营养药物）和对照组（神经营养药物）。治疗组除了正常治疗额外口服多奈哌齐5～10mg／d，疗程16周。采用蒙特利尔认知功能检查量表（MoCA）和简易精神状态量表（MMSE）于治疗前和治疗16周时进行认知功能的评定。结果治疗组在治疗后其认知功能在MoCA和MMSE量表评分上分别提高（3．2±2．7）和（3．5±3．2）分，与对照组对比，差异有统计学意义（t=5．40、3．88，P〈0．01），而且在视空间与执行功能、命名、注意力、抽象思维、延迟回忆均有改善提高，差异有统计学意义（t=-3．55、-3．08、-3．21、-2．58、-3．65，P〈0．05），对照组则对应项目的评分基本不变。结论多奈哌齐联合常规神经营养药物治疗放射性脑病引起认知功能的损害有较好的疗效，并能有效地改善、维持患者的生活质量，

英文摘要：

Objective To evaluate the efficacy and safety of donepezil in the treatment of cognitive dysfunction caused by radiation-induced encephalopathy. Methods A total of fifty-five patients with radiation-induced cognitive impairment were divided into treatment group with extra donepezil 5-10 mg/d combined with conventional therapy and control group with conventional treatment for 16 weeks. The cognitive function was assessed according to Montreal cognitive assessment （MoCA） and mini-mental state examination （MMSE） before and 16 weeks after treatment. Results After 16 weeks of treatment, the patients in treatment group displayed significantly greater improvement in cognitive function. In treatment group, the scores of patients after donepezil therapy in MoCA and MMSE were obviously higher than the control group （ t = 5.40, 3.88, P 〈 0. 01 ）. The scores in the visual space and executive function, naming, attention, abstract thinking, delayed memories also had improved, which suggested the statistically significant difference（t= -3.55, -3.08, -3.21, -2.58, -3.65, P〈0.05）. The scores of control group unchanged accordingly. Conclusions Donepezil combined with conventional treatment was signally effective in the therapy of cognitive dysfunction caused by radiation-induced cncephalopathy.