中文摘要：

目的研究深度水解蛋白配方奶粉（EHF）对坏死性小肠结肠炎（NEC）术后肠内营养（EN）建立的贡献。方法采用随机双盲对照的方法,将符合纳入标准的病例分为EHF组（EHF喂养）与SF组（普通早产儿配方奶喂养）,制定试验方案与流程,严格质量管理,手术后即给予肠外营养（PN）,1 d内即给予足量氨基酸脂肪乳,奶量按照70%折算到输液量中,微量喂养（MEN）期间不计热量,并根据EN的增加相应减少PN,奶量达120 ml·kg^-1·d^-1停止输液,热量目标为100 kcal·kg^-1·d^-1）。EN：术后经评估达开奶指征后,两组分别开奶,采取MEN方案：以10～20 ml·kg^-1·d^-1开奶,1次/3 h,加奶量为10～20 ml·kg^-1·d^-1,喂养过程中如出现喂养不耐受（FI）,暂缓加奶,暂禁食,待症状解除后,继续进行EN。至NEC术后2周EHF组也改为普通早产儿配方奶。结果 EHF组、SF组各纳入27例患儿,均完成试验并按时随访。2组患儿性别、出生胎龄、出生体重及纳入观察时体重、完成试验时、矫正胎龄1个月龄时体重、试验期间能量摄入、蛋白质/氨基酸摄入、脂肪摄入、体格增长（体重、身长、头围）、术后住院时间差异均无统计学意义（P〉0.05）;试验期间大便pH值及尿比重、血气、离子水平、肝肾功能等生化指标多无明显异常与偏离,将白蛋白、前白蛋白、血尿素氮3项指标进行比较,差异均无统计学意义（P〉0.05）;术后均未见NEC复发病例;达到全EN的时间、FI累计时间、大便隐血试验阳性,2组比较差异有统计学意义（P〈0.05）。结论 NEC术后采用EHF喂养能安全有效建立EN。

英文摘要：

Objective To study the role of extensive hydrolyzed formula milk（ EHF） in establishment of enteral nutrition（ EN） of preterm infants after necrotizing enterocolitis（ NEC） surgery. Methods A random,double-blinded,case-control study was conducted,the premature infants meeting the inclusion criteria were divided into EHF group（ fed by EHF） and standard formula group（ fed by standard formula milk）,programme and procedure were constituted and administered blindedly. Parenteral nutrition（ PN） was administered as soon as finishing operation and such elements as amino acids and fat were prescribed to total dosages. Energy of EN accounted for 70% of milk while minimal enteral nutrition（ MEN） was ignored,PN decreased while EN increased. When EN reached 120 ml·kg^-1·d^-1,PN finished. The goal of energy was 100 k Cal·kg^-1·d^-1. EN： after operation,when the criteria were identified,the infants in the two groups began to be fed respectively by MEN programme： the start dose was 10-20 ml·kg^-1·d^-1,they were fed every 3 hours and milk dose increased on the speed of 10-20 ml·kg^-1·d^-1,feeding termination and absolute diet were adopted for the infants with feeding intolerance,EN continued after symptomatic relief. The infants in EHF group were fed by standard formula milk after 2 weeks of surgery. Results A total of 54 infants were included into the two groups,27 infants in each group,and all the infants finished trial and follow-up on time. There was no statistically significant difference in gender,gestational age at brith,birth weight,weight of entering trial,weight of finishing trial and weight at the corrected gestational age of one month,energy intake,protein / amino acids intake,and fat intake,the growth of weight,body length,and head circumtance,hospitalization time after surgery between the two groups. Stool p H,urine gravity,blood gas,ion,hepatic and renal function and other biochemical findings during the study didnot deviate significantly; there was no statistically significant