中文摘要：

在室温、甲醇水溶剂条件下，以盐酸为酸催化剂，以2-嘧啶氧基-N-芳基苄胺衍生物为反应原料，基于高效液相色谱（HPLC）监测，能快速、高效、便捷地实现Smiles重排反应.本方法的优点在于反应体系溶剂可重复利用，在无需分离的条件下即可取得良好的产率和纯度.从催化剂和溶剂的廉价以及反应的高效简便和绿色温和角度考虑，该合成方法具有较好的实用性和绿色经济性.

英文摘要：

Based on high performance liquid chromatography （HPLC）, a fast, efficient and simple route for Smiles rearrangement reaction has been developed in the presence of 2-pyrimidinyloxy-N-arylbenzylamine derivatives as reactants with HCl as acid catalyst in mixed CH3OH/H2O medium at room temperature. The advantage of the proposed method is that the products with excellent yields and high purity can be obtained employing reused solvent without further separating process. Considering the cheapness of catalyst and solvent, as well as high efficient and environment-friendly reaction condition, the developed method has the practicability and environmentally friendliness.