呋喃是一类重要的杂环化合物,该类化合物不仅是许多天然产物的核心结构单元,而且大多具有生物活性,在医药、农药以及生物化学方面有着广泛的应用。本文综述了由过渡金属催化的以非环化合物为前体的呋喃衍生物合成的最新研究进展。重点阐述了以联烯酮、炔酮、(Z)-2-烯-4-炔-1-醇(酮)、炔基环氧化物、2-(1-炔基)-2-烯-1-酮这5类化合物为前体的呋喃合成方法,概述了其他一些具有代表性的方法,并展望了呋喃衍生物合成的研究和发展方向。
The furan rings constitute an important class of heterocycles,which behave not only as key structural subunits in numerous natural products,but also display wide range of bioactivities.They also have applications in medicine,agricultural chemicals and biological chemistry.This review focuses on the recent progress in transition metal-catalyzed synthesis of furan derivatives from acyclic precursors such as allenyl ketones,alkynones,(Z)-2-en-4-yn-1-ols(or-ones),alkynyl epoxides,2-(1-alkynyl)-2-alken-1-ones.The research trend for the synthesis of furan derivatives is also prospected.