高分辨率的原子磁性的回声(NMR ) 是为分析分子的结构和动力学的最强大的工具之一。磁场同质为常规高分辨率的系列被要求。然而,有许多化学或生物的情形,磁场的空间同质被降级。强烈溶剂信号在 vivo 并且在 situ NMR 光谱学是为获得高分辨率的系列的另一个障碍,在特别。在这份报纸,一个新脉搏序列基于分子间的多重量连贯(iMQC ) 被报导。这个序列能有效地移开磁场不同类的效果并且压制溶剂信号。它能恢复光谱信息象化学移动,联合常数,多重谱线模式,和相对山峰那样不同类的地里的区域。理论分析和试验性的确认被介绍表明这个方法的可行性。
High-resolution nuclear magnetic resonance (NMR) is one of the most powerful tools for analyzing molecular structures and dynamics. Magnetic field homogeneity is required for conventional high-resolution spectra. However, there are many chemical and/or biological circumstances where the spatial homogeneities of the magnetic fields are degraded. Intense solvent signal is another obstacle for obtaining high-resolution spectra, especially in in vivo and in situ NMR spectroscopy. In this paper, a new pulse sequence based on intermolecular multiple quantum coherence (iMQC) was reported. This sequence can effectively remove the effect of magnetic field inhomogeneity and suppress the solvent signal. It can recover the spectral information such as chemical shifts, coupling constants, multiplet patterns, and relative peak areas in inhomogeneous fields. Theoretical analyses and experimental verifications are presented to demonstrate the feasibility of this method.