中文摘要：

长链非编码RNAs（1ncRNAs）是一类剪切本大于200bp，缺少开放阅读框，不编码蛋白的非编码RNAs，在生物体内能够调控基因、蛋白等的表达，调节细胞机体代谢，进而发挥生物学功能，在肿瘤发生、发展及转移过程中发挥重要作用。近年研究发现，非小细胞肺癌（NSCLC）患者占肺癌患者的85％左右，并且NSCLC患者的5年生存率较低。本文通过对长链非编码RNA的来源、功能及在NSCLC的分子生物机制的深入探讨，为NSCLC的诊断、治疗及预后提供重要科学理论及应用价值。

英文摘要：

The long non-coding RNAs （LncRNAs） are a group of RNA transcripts which are in length over 200nt and have no protein-coding capacity because of lacking of significant open reading frames （ORFs）. lncRNAs regulate gene expression and are involved in cell biological functions which play an important role in the process of tumor development and metastasis. The non-small cell lung cell （NSCLC） is about 85% of lung cancer and the patients have a low five year survival rate. The deep understanding of lncRNAs sources, functions and the molecular biological mechanisms in NSCLC provide essential theories and practical values in the diagnosis, treatment and prognosis.