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Clinical and pathological features of miR-10b and RHOC gene expression in hepatocellular carcinoma

ISSN号：1000-3282
期刊名称：《生物化学与生物物理进展》
时间：0
分类：Q78[生物学—分子生物学] S851.347[农业科学—预防兽医学;农业科学—兽医学;农业科学—畜牧兽医]
作者机构：1. Department of Pathology, Chinese PLA General Hospital, Beijing, 100853, China2. Department of Pathology, Urumqi General Hospital, Lanzhou Military District, Urumqi, 830054, China3. Department of Biochemistry and Molecular Biology, Beijing Institute of Radiation Medicine, Beijing, 100850, China4. Institute of Tuberculosis, 309th Hospital PLA, Beijing, 100091, China5. Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, 100853, China
相关基金：supported by the National Basic Research Program of China (2012CB934002, 2010CB912802);National High-tech R&D Program of China (2012AA02A203, 2012AA02A209, 2012AA02A504);National Key Scientific instrument Special Program of China (2011YQ03013405);the National Natural Science Foundation of China (81121004, 81071953, 81161120432);National Key Scientific Research Program of China (Grant No. 2010CB912801)

作者： Jingli Du Yulan Wang Hanjiang Fu Xiaofei Zheng Minggui Lin Mingzhou Guo Lixin Wei

关键词：肝癌, 病理特征, OC基因, microRNA, 临床, RH, MRNA降解, miRNA, miR-10b , RHOC, Hepatocellularcarcinoma, miRNA , Metastasis

中文摘要：

microRNAs (miRNAs ) 的异常表示在不同人的癌症经常被报导。miRNA 的主要角色正在指向编码基因并且引起翻译压抑或 mRNA 降级的 3-UTR。miR-10b overexpression 被报导由起来调整的 RHOC 表示支持乳癌转移。但是它在 hepatocellular 癌(HCC ) 的表示仍然保持不清楚。我们的学习显示 miR-10b 的表示在 HCC 和邻近的织物样品是不同的，并且在 HCC 减少了 miR-10b 的表示与静脉侵略有关。RHOC 的高级表示也与在 HCC 的静脉侵略有关。但是没有关联在 miR-10b 和 RHOC 表示之间被发现。这些结果建议 miR-10b 和 RHOC 是 HCC 侵略和转移的独立预言者。

英文摘要：

Aberrant expression of microRNAs （miRNAs） was reported frequently in different human cancers. The major role of miRNA is targeting 31-UTR of coding gene and causing translational repression or mRNA degradation. miR-10b overexpression was reported to promote breast cancer metastasis by up-regulating RHOC expression. But its expression in hepatocellular carcinoma （HCC） remains unclear. Our study indicated that the expression of miR-10b was different in HCC and adjacent tissue samples, and reduced expression of miR-10b in HCC was related tovein invasion. High-level expression of RHOC was also related to vein invasion in HCC. But no correlation was found between miR-10b and RHOC expression. These results suggest that miR-10b and RHOC are independent predictors of HCC invasion and metastasis.